Nature Search

Brain insulin sensitivity is linked to adiposity and body fat distribution

Brain insulin action regulates eating behavior and whole-body energy fluxes, however the impact of brain insulin resistance on long-term weight and body fat composition is unknown. Here, the authors show that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution.

Stephanie Kullmann
Vera Valenta
Martin Heni
ResearchOpen Access15 Apr 2020
Nature Communications

Volume: 11, P: 1-6
The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women

Central insulin effects on brain networks and food cue reactivity in the hippocampus and striatum vary dynamically across the menstrual cycle in premenopausal women, with estradiol and progesterone predicting these changes.

Julia Hummel
Sixiu Zhao
Stephanie Kullmann
ResearchOpen Access06 Jan 2026
Communications Biology

Volume: 9, P: 1-12
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

In young women, brain insulin action enhances peripheral insulin sensitivity, but only during the follicular phase of the menstrual cycle. This effect is absent in the luteal phase, possibly due to hypothalamic insulin resistance.

Julia Hummel
Charlotte Benkendorff
Martin Heni
ResearchOpen Access21 Sept 2023
Nature Metabolism

Volume: 5, P: 1475-1482
Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights

In a randomized, crossover clinical trial in healthy young adults with varying weights, sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motivation and somatosensory processing.

Sandhya P. Chakravartti
Kay Jann
Kathleen A. Page
Research26 Mar 2025
Nature Metabolism

Volume: 7, P: 574-585
Gene therapy in epilepsy—is it time for clinical trials?

Kullmann et al. discuss the need for gene therapy in epilepsy and the challenges of translating experimental research into the clinic. Furthermore, they outline the potential for gene therapy strategies in pharmacoresistant epilepsy, ways to assess therapeutic efficacy, and the need to evaluate long-term safety data.

Dimitri M. Kullmann
Stephanie Schorge
Robert C. Wykes
Reviews18 Mar 2014
Nature Reviews Neurology

Volume: 10, P: 300-304
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Genetic variants in ionotropic glutamate receptors have been implicated in neurodevelopmental disorders. Here, the authors report heterozygous de novo mutations in the GRIA2 gene in 28 individuals with intellectual disability and neurodevelopmental abnormalities associated with reduced Ca²⁺ transport and AMPAR currents.”

Vincenzo Salpietro
Christine L. Dixon
Henry Houlden
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Stephanie Kullmann
Martin Heni
Hubert Preissl
ResearchOpen Access09 May 2017
Scientific Reports

Volume: 7, P: 1-10
A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.

Stephanie Kullmann
Lore Wagner
Andreas L. Birkenfeld
ResearchOpen Access21 Feb 2025
Nature Metabolism

Volume: 7, P: 469-477
Chemical–genetic attenuation of focal neocortical seizures

Focal epilepsy is difficult to treat with currently available drugs or surgical approaches. Kätzel et al.express mutant inhibitory receptors in the brains of rats with focal epilepsy and selectively activate these receptors by an exogenous compound, which results in region- and time-specific suppression of focal seizures

Dennis Kätzel
Elizabeth Nicholson
Dimitri M. Kullmann
ResearchOpen Access27 May 2014
Nature Communications

Volume: 5, P: 1-9
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

The potassium-chloride co-transporter, KCC2 is an essential component in maintaining a gradient for chloride ions in neurons. Here Stodberg and colleagues identify loss-of-function mutations in the encoding geneSLC12A5, which impair normal synaptic function associated with early-onset epilepsy.

Tommy Stödberg
Amy McTague
Manju A. Kurian
ResearchOpen Access03 Sept 2015
Nature Communications

Volume: 6, P: 1-9
Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children

Sixiu Zhao
Lorenzo Semeia
Stephanie Kullmann
ResearchOpen Access28 Aug 2024
International Journal of Obesity

Volume: 48, P: 1728-1734
Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Biochemical autoregulatory gene therapy for focal epilepsy

A glutamate-gated chloride channel delivered via gene therapy is shown to detect elevated brain glutamate levels and trigger the suppression of neuronal excitability, thereby attenuating seizure activity in two rodent models of epilepsy.

Andreas Lieb
Yichen Qiu
Dimitri M. Kullmann
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1324-1329
Impaired insulin action in the human brain: causes and metabolic consequences

In this Review, Martin Heni and colleagues outline the effects of insulin in the brain in humans and the relevance of the effects for physiology. The metabolic consequences of brain insulin resistance are discussed and possible future approaches to overcome brain insulin resistance and thereby prevent or treat obesity and type 2 diabetes mellitus are outlined.

Martin Heni
Stephanie Kullmann
Hans-Ulrich Häring
Reviews13 Oct 2015
Nature Reviews Endocrinology

Volume: 11, P: 701-711
Health, pleasure, and fullness: changing mindset affects brain responses and portion size selection in adults with overweight and obesity

Ralf Veit
Lisa I. Horstman
Stephanie Kullmann
Research18 Jun 2019
International Journal of Obesity

Volume: 44, P: 428-437
Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Theresa Ester-Nacke
Katharina Berti
Stephanie Kullmann
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-11
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Lore Wagner
Ralf Veit
Stephanie Kullmann
ResearchOpen Access17 Jun 2022
International Journal of Obesity

Volume: 46, P: 1662-1670
Dusp8 affects hippocampal size and behavior in mice and humans

Peter Baumann
Sonja C. Schriever
Paul T. Pfluger
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Myotonia in a patient with a mutation in an S4 arginine residue associated with hypokalaemic periodic paralysis and a concomitant synonymous CLCN1 mutation

Michael G. Thor
Vinojini Vivekanandam
Roope Männikkö
ResearchOpen Access26 Nov 2019
Scientific Reports

Volume: 9, P: 1-11

Search

Brain insulin sensitivity is linked to adiposity and body fat distribution

The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women

Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights

Gene therapy in epilepsy—is it time for clinical trials?

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Chemical–genetic attenuation of focal neocortical seizures

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children

Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Biochemical autoregulatory gene therapy for focal epilepsy

Impaired insulin action in the human brain: causes and metabolic consequences

Health, pleasure, and fullness: changing mindset affects brain responses and portion size selection in adults with overweight and obesity

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Dusp8 affects hippocampal size and behavior in mice and humans

Myotonia in a patient with a mutation in an S4 arginine residue associated with hypokalaemic periodic paralysis and a concomitant synonymous CLCN1 mutation

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