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Showing 1–4 of 4 results
Advanced filters: Author: Steven E. Pilley Clear advanced filters

  • In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreased ALDH1L2 expression is accompanied by formate overflow, which can be used to monitor PDAC progression.

    • Marc Hennequart
    • Loic Mervant
    • Karen H. Vousden
    ResearchOpen Access
    Nature Metabolism
    P: 1-14

  • To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation improves ovarian hormone profiles, follicle metrics and fertility-related outcomes, highlighting a causal role for the aging gut microbiome in regulating ovarian function.

    • Minhoo Kim
    • Justin Wang
    • Bérénice A. Benayoun
    ResearchOpen Access
    Nature Aging
    Volume: 6, P: 682-702

  • Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensitive to serine withdrawal.

    • Marc Hennequart
    • Christiaan F. Labuschagne
    • Karen H. Vousden
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10