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Showing 1–2 of 2 results
Advanced filters: Author: Subhamoy Chakraborty Clear advanced filters

  • Small-cell lung cancer (SCLC) is a highly aggressive cancer type with immunosuppressed phenotype. Here, the authors find that depletion of nonhomologous end joining DNA repair regulator PRKDC is able to induce activation of the cGAS/STING pathway and potentiate the efficacy of immunotherapy in SCLC pre-clinical models.

    • Subhamoy Chakraborty
    • Andrew Elliott
    • Triparna Sen
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-23

  • Traditionally, patients with small-cell lung cancer (SCLC), a malignancy with a dismal prognosis, have had limited treatment options. Over the past few years, advances in the molecular characterization of SCLC have revealed novel therapeutic targets. The authors of this Review summarize these findings and discuss emerging opportunities and challenges for their translation into new treatment approaches.

    • Triparna Sen
    • Nobuyuki Takahashi
    • Abdul Rafeh Naqash
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 21, P: 610-627