Nature Search

Smart adaptive learning and optimized feature clustering for enhanced image retrieval

P. Umaeswari
Sujata Patil
Przemysław Falkowski-Gilski
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.

Maria Carmen Inda
Suhasini Joshi
Gabriela Chiosis
ResearchOpen Access16 Jan 2020
Nature Communications

Volume: 11, P: 1-19
Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review

Karen A Cadoo
Devika Gajria
Tiffany A Traina
ResearchOpen Access30 Mar 2016
npj Breast Cancer

Volume: 2, P: 1-5
Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors

Chandarlapaty and colleagues use longitudinal ctDNA samples to identify genomic alterations in PTEN and ESR1 associated with resistance in a phase I/II trial of a PI3K inhibitor and aromatase inhibition for hormone receptor–positive metastatic breast cancer.

Pedram Razavi
Maura N. Dickler
Sarat Chandarlapaty
Research23 Mar 2020
Nature Cancer

Volume: 1, P: 382-393
The epichaperome is an integrated chaperome network that facilitates tumour survival

Chaperomes are dynamic assemblies of proteins that regulate cellular homeostasis but specific cellular stresses remodel chaperome components into a stable chaperome network called the epichaperome, which might offer a new cancer target.

Anna Rodina
Tai Wang
Gabriela Chiosis
Research05 Oct 2016
Nature

Volume: 538, P: 397-401
A rectal cancer organoid platform to study individual responses to chemoradiation

Rectal cancer organoids retain the pathological features of matched patient tumors and recapitulate clinical responses to chemoradiation.

Karuna Ganesh
Chao Wu
J. Joshua Smith
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1607-1614
Extended spectrum of cancers in PTEN hamartoma tumor syndrome

Lamis Yehia
Gilman Plitt
Charis Eng
ResearchOpen Access06 Mar 2025
npj Precision Oncology

Volume: 9, P: 1-8
Predictors of response to CDK4/6i retrial after prior CDK4/6i failure in ER+ metastatic breast cancer

Nicholas Mai
Carlos H. dos Anjos
Komal Jhaveri
ResearchOpen Access18 Oct 2024
npj Breast Cancer

Volume: 10, P: 1-9
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Shruti V. Patil
Balasankara Reddy Kaipa
Gulab S. Zode
ResearchOpen Access23 Mar 2024
Scientific Reports

Volume: 14, P: 1-13
Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab

Emanuela Ferraro
Jasmeet Singh
Chau T. Dang
ResearchOpen Access22 Mar 2022
npj Breast Cancer

Volume: 8, P: 1-8
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases

David B. Page
Kathryn Beal
Heather L. McArthur
ResearchOpen Access19 Apr 2022
npj Breast Cancer

Volume: 8, P: 1-11
The clinical behavior and genomic features of the so-called adenoid cystic carcinomas of the solid variant with basaloid features

Christopher J. Schwartz
Edi Brogi
Hannah Y. Wen
Research01 Oct 2021
Modern Pathology

Volume: 35, P: 193-201
Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma

Raza Syed Hoda
Edi Brogi
Hannah Yong Wen
Research01 Jul 2020
Modern Pathology

Volume: 33, P: 2221-2232

Search

Smart adaptive learning and optimized feature clustering for enhanced image retrieval

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review

Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors

The epichaperome is an integrated chaperome network that facilitates tumour survival

A rectal cancer organoid platform to study individual responses to chemoradiation

Extended spectrum of cancers in PTEN hamartoma tumor syndrome

Predictors of response to CDK4/6i retrial after prior CDK4/6i failure in ER+ metastatic breast cancer

Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab

Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases

The clinical behavior and genomic features of the so-called adenoid cystic carcinomas of the solid variant with basaloid features

Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma

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