The STAT3 pathway is activated in B cells by interleukin-6 and interleukin-21; however, methylation of Lys140 prevents its dephosphorylation and deactivation. Yin et al. report a noncanonical role for the histone demethylase Jmjd1c in demethylating phosphorylated STAT3, thereby terminating B cell activation and limiting plasma cell generation and potential B cell-mediated autoimmunity.
- Yuye Yin
- Xinyi Yang
- Xiaoming Wang
