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Showing 1–11 of 11 results

Advanced filters: Author: Sumiyo Morita Clear advanced filters

Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice

The authors develop a system to erase DNA methylation at H19-DMR in mouse sperm. Despite loss, methylation partly recovers via H3K9me3 after fertilization, revealing partial intergenerational epigenetic inheritance.

Takuro Horii
Sumiyo Morita
Izuho Hatada
ResearchOpen Access25 Dec 2025
Nature Communications

Volume: 16, P: 1-15
Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering

Takuro Horii
Yuji Arai
Izuho Hatada
ResearchOpen Access28 Mar 2014
Scientific Reports

Volume: 4, P: 1-6
Efficient generation of conditional knockout mice via sequential introduction of lox sites

Takuro Horii
Sumiyo Morita
Izuho Hatada
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity

Sumiyo Morita
Kazuhiko Nakabayashi
Izuho Hatada
ResearchOpen Access12 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

DNA methyl groups are selectively removed at target loci using inactive Cas9 fused to a SunTag-based peptide repeat that recruits the enzymatic activity.

Sumiyo Morita
Hirofumi Noguchi
Izuho Hatada
Research29 Aug 2016
Nature Biotechnology

Volume: 34, P: 1060-1065
Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells

Izuho Hatada
Sumiyo Morita
Kenta Nakai
Research01 Feb 2008
Journal of Human Genetics

Volume: 53, P: 185-191
Microarray analysis of promoter methylation in lung cancers

Masayuki Fukasawa
Mika Kimura
Izuho Hatada
Research01 Apr 2006
Journal of Human Genetics

Volume: 51, P: 368-374
The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells

Ryosuke Kobayashi
Yuki Tajika
Izuho Hatada
ResearchOpen Access08 Aug 2024
Cell Death Discovery

Volume: 10, P: 1-11
Anephrogenic phenotype induced by SALL1 gene knockout in pigs

Masahito Watanabe
Kazuaki Nakano
Hiroshi Nagashima
ResearchOpen Access29 May 2019
Scientific Reports

Volume: 9, P: 1-11
Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing

Nozomi Hanzawa
Koshi Hashimoto
Yoshihiro Ogawa
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-14
p53 Suppresses Tetraploid Development in Mice

Takuro Horii
Masamichi Yamamoto
Izuho Hatada
ResearchOpen Access10 Mar 2015
Scientific Reports

Volume: 5, P: 1-9