Nature Search

Ether lipids influence cancer cell fate by modulating iron uptake

The contribution of ether lipid species in cancer cell fate has not been fully understood yet. Here the authors show that malignant cancer cells employ ether lipids to modulate membrane biophysical properties, enhancing iron endocytosis and ferroptosis susceptibility.

Ryan P. Mansell
Sebastian Müller
Whitney S. Henry
ResearchOpen Access27 Jan 2026
Nature Communications

P: 1-19
A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases

Existing methods for the modification of exosomes adversely impact structures and functions of exosomal proteins and membranes. Here, the authors develop a chemically engineered platform by leveraging the synergistic interplay between CD38’s catalytic activity and the covalent inhibitor 2'-Cl-araNAD⁺.

Lei Zhang
Srinivasarao Singireddi
Yong Zhang
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Deployment of a cloud-based passive defecation monitoring system for continuous gut health monitoring

In this protocol, the authors explain how to set up and use the cloud-based Precision Health Integrated Diagnostic (PHIND) system, a smart-toilet-based platform for passive and automated defecation monitoring to provide continuous gut health information.

Zhiquan Song
Minso Kim
Seung-min Park
Protocols09 Jan 2026
Nature Protocols

P: 1-30
Precision nutrition for hypertension: tea, coffee, antioxidant vitamins interactions with polygenic risk in multi-ethnic populations

Haeng Jeon Hur
Hye Jeong Yang
Sunmin Park
Research08 Jan 2026
European Journal of Clinical Nutrition

P: 1-15
An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models

An optimized agonist of Nurr1, 4A7C-301, protects dopamine neurons against environmental and genetic risk factors of Parkinson’s disease (PD) in vitro, and improves both motor and non-motor deficits in male rodent models of PD.

Woori Kim
Mohit Tripathi
Kwang-Soo Kim
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Programmed death-ligand 1 (PD-L1) is involved in the inhibition of antigen specific T cells via ligation of programmed death 1 (PD-1). Here, the authors show checkpoint inhibition by use of small molecule inhibition of PD-L1 which in a humanised mouse model was shown to restore T cell responses and reduced tumour burden.

Jang-June Park
Emily P. Thi
Chris B. Moore
ResearchOpen Access22 Feb 2021
Nature Communications

Volume: 12, P: 1-11
A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming

A regulated stress response is essential for healthy child growth and development. Here, the authors show that a nutrition, water, sanitation, and hygiene intervention enhanced adaptive responses of the physiological stress system in early childhood.

Audrie Lin
Andrew N. Mertens
Douglas A. Granger
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-12
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.

Joonseok Cho
Yujian Zhang
Naohiro Terada
ResearchOpen Access16 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Correction: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Joonseok Cho
Yujian Zhang
Naohiro Terada
Amendments and CorrectionsOpen Access18 Aug 2017
Nature Communications

P: 1-4
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Understanding gender and age differences in language use: cross-cultural insights from Weibo and Facebook

Dandan Pang
Sharath Chandra Guntuku
Lyle H. Ungar
ResearchOpen Access31 Oct 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-18
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions

While transcriptomics have enhanced our understanding for cancer, spatial transcriptomics enable the characterisation of cellular interactions. Here, the authors integrate single cell data with spatial information for HER2 + tumours and develop tools for the prediction of interactions between tumour-infiltrating cells.

Alma Andersson
Ludvig Larsson
Joakim Lundeberg
ResearchOpen Access14 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning

Deep learning algorithms perform as well as humans in identifying cells in tissue images.

Noah F. Greenwald
Geneva Miller
David Van Valen
Research18 Nov 2021
Nature Biotechnology

Volume: 40, P: 555-565
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Naloxone’s dose-dependent displacement of [¹¹C]carfentanil and duration of receptor occupancy in the rat brain

Yeona Kang
Kelly A. O’Conor
Nora D. Volkow
ResearchOpen Access19 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
A risk of serious anaphylatic reactions to asthma biologics: a pharmacovigilance study based on a global real-world database

Sunny Park
Yeju Kim
Soo An Choi
ResearchOpen Access17 Oct 2023
Scientific Reports

Volume: 13, P: 1-7
Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

These two studies show that primary cilia can either mediate or suppress tumorigenesis in models of basal cell carcinoma and medulloblastoma, respectively, depending on the nature of the initial oncogenic event (pages 994–996) and (pages 1062–1065).

Sunny Y Wong
Allen D Seol
Jeremy F Reiter
Research23 Aug 2009
Nature Medicine

Volume: 15, P: 1055-1061
The discriminatory capability of existing scores to predict advanced colorectal neoplasia: a prospective colonoscopy study of 5,899 screening participants

Martin C. S. Wong
Jessica Y. L. Ching
Joseph J. Y. Sung
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

B Kucejova
N E Sunny
J Brugarolas
Research10 Jan 2011
Oncogene

Volume: 30, P: 2147-2160
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters

Héctor I. Navarro
Allison E. Daly
Alexander Hoffmann
ResearchOpen Access11 Feb 2025
Cell Discovery

Volume: 11, P: 1-12
Advances and challenges of operational seasonal prediction in Pacific Island Countries

Yun-Young Lee
WonMoo Kim
Sunny K. Seuseu
ResearchOpen Access06 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Impact of recent climate change on corn, rice, and wheat in southeastern USA

Ramandeep Kumar Sharma
Sunny Kumar
Krishna N. Reddy
ResearchOpen Access08 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Investigation of [¹¹C]carfentanil for mu opioid receptor quantification in the rat brain

Andrew C. Kelleher
Torben D. Pearson
Sung Won Kim
ResearchOpen Access15 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Deep phenotyping and genomic data from a nationally representative study on dementia in India

Jinkook Lee
Sarah Petrosyan
Aparajit B. Dey
ResearchOpen Access20 Jan 2023
Scientific Data

Volume: 10, P: 1-12

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