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Showing 1–6 of 6 results
Advanced filters: Author: Sushant Bangru Clear advanced filters

  • Liver regeneration often fails during chronic liver disease. Here, the authors conduct multiomic profiling of human livers to demonstrate that RNA splicing is dysregulated in alcohol-associated liver disease, interfering with liver regeneration.

    • Ullas V. Chembazhi
    • Sushant Bangru
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.

    • Sushant Bangru
    • Rocky Diegmiller
    • Kenneth D. Poss
    Reviews
    Nature Reviews Molecular Cell Biology
    P: 1-20

  • Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hepatocellular gene expression, metabolism, and lipid trafficking, resulting in NASH-like pathology.

    • Waqar Arif
    • Bhoomika Mathur
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19