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CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

In this multicenter phase 1 trial, treatment with IBI343, a CLDN18.2-targeting antibody–drug conjugate, was safe and showed encouraging clinical responses in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

Jia Liu
Jianwei Yang
Lin Shen
ResearchOpen Access16 Jul 2025
Nature Medicine

Volume: 31, P: 3028-3036
Defective states of Hermite-Gaussian modes for long-distance image transmission and high-capacity encoding

The authors propose a method for high-capacity information encoding and long-distance image transmission by utilising Hermite-Gaussian eigenmodes in defective states. The enables the generation over 10ⁿ varying laser states for encoding, or an information capacity of tens of bits.

Zilong Zhang
Yuqi Wang
Changming Zhao
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-10
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Yan Song
Bo Zhang
Jing Huang
ResearchOpen Access02 Feb 2023
Nature Medicine

Volume: 29, P: 473-482
Rising importance of agricultural nitrogen oxide emissions in China’s future PM_2.5 pollution mitigation

Yuanhong Zhao
Zhanpeng Su
Lin Zhang
ResearchOpen Access07 Mar 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-8
Nuclear Aurora kinase A switches m⁶A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

SiSi Li
YangFan Qi
Quentin Liu
ResearchOpen Access01 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
A non-carboxylating pentose bisphosphate pathway in halophilic archaea

A nucleoside degradation pathway in halophilic archaea is identified, which converts the ribose moiety of guanosine to dihydroxyacetone phosphate and ethylene glycol.

Takaaki Sato
Sanae (Hodo) Utashima
Haruyuki Atomi
ResearchOpen Access24 Nov 2022
Communications Biology

Volume: 5, P: 1-13
Several anthropometric measurements and cancer mortality: predictor screening, threshold determination, and joint analysis in a multicenter cohort of 12138 adults

Liangyu Yin
Ling Zhang
Hongxia Xu
Research28 Sept 2021
European Journal of Clinical Nutrition

Volume: 76, P: 756-764

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CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial

Defective states of Hermite-Gaussian modes for long-distance image transmission and high-capacity encoding

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

Rising importance of agricultural nitrogen oxide emissions in China’s future PM2.5 pollution mitigation

Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

A non-carboxylating pentose bisphosphate pathway in halophilic archaea

Several anthropometric measurements and cancer mortality: predictor screening, threshold determination, and joint analysis in a multicenter cohort of 12138 adults

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Rising importance of agricultural nitrogen oxide emissions in China’s future PM_2.5 pollution mitigation

Nuclear Aurora kinase A switches m⁶A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4