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Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors

Barcia Durán, Dayasagar, et al. map the expression of immune checkpoints in human atherosclerosis and examine the influence of lipid-lowering treatments and type 2 diabetes to understand how immune checkpoint inhibitors worsen cardiovascular risk in survivors of cancer.

José Gabriel Barcia Durán
Dayasagar Das
Chiara Giannarelli
ResearchOpen Access29 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1482-1502
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

Eberhardt et al. show that SARS-CoV-2 infects human coronary lesions where it preferentially targets plaque macrophages, triggering plaque inflammation and potentially leading to acute cardiovascular complications and long-term cardiovascular risks in patients with COVID-19.

Natalia Eberhardt
Maria Gabriela Noval
Chiara Giannarelli
ResearchOpen Access28 Sept 2023
Nature Cardiovascular Research

Volume: 2, P: 899-916
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

Amadori et al. show that plasma from patients with atherosclerosis triggers unique inflammatory transcriptomic and signaling signatures in peripheral blood mononuclear cells, which were used for selecting drugs that may be repurposed for the treatment of atherosclerosis.

Letizia Amadori
Claudia Calcagno
Chiara Giannarelli
ResearchOpen Access08 Jun 2023
Nature Cardiovascular Research

Volume: 2, P: 550-571
Publisher Correction: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

Letizia Amadori
Claudia Calcagno
Chiara Giannarelli
Amendments and CorrectionsOpen Access04 Jul 2023
Nature Cardiovascular Research

Volume: 2, P: 793

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Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

Publisher Correction: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

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