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Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

Cancer stem cells are a sub-population of tumour cells but how they interact with the tumour microenvironment is unclear. Here, Chen et al.culture lung cancer stem cells with cancer-associated fibroblasts and delineate a signalling pathway between the two cells that helps maintain the cancer stem cell state.

Wan-Jiun Chen
Chao-Chi Ho
Pan-Chyr Yang
Research25 Mar 2014
Nature Communications

Volume: 5, P: 1-17
An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning

Deep learning for digital pathology is hindered by the extremely high spatial resolution of whole slide images (WSIs), which requires researchers to adopt patch-based methods and laborious free-hand contouring. Here, the authors develop a whole-slide training method to classify types of lung cancers using slide-level diagnoses with deep learning.

Chi-Long Chen
Chi-Chung Chen
Cheng-Yu Chen
ResearchOpen Access19 Feb 2021
Nature Communications

Volume: 12, P: 1-13
MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

Lung cancers have a high potential to become metastatic, which is a major cause of treatment failure. Here, the authors identify a microRNA that is upregulated in non-small-cell lung cancer and is associated with Hippo pathway modulation metastasis and poor clinical outcome.

Ching-Wen Lin
Yih-Leong Chang
Pan-Chyr Yang
Research21 May 2013
Nature Communications

Volume: 4, P: 1-14
pH-controlled stacking direction of the β-strands in peptide fibrils

Wei-Hsuan Tseng
Szu-Hua Chen
Hirotsugu Hiramatsu
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma

LCRMP-1 serves as a transcriptional co-regulator that enhances the transcription of SERPINE1, thereby facilitating angiogenesis in lung adenocarcinoma.

Yuan-Ling Hsu
Pei-Fang Hung
Szu-Hua Pan
ResearchOpen Access25 Nov 2025
Communications Biology

Volume: 8, P: 1-16
Boron nitride for applications in microelectronics

This Perspective provides an overview of boron nitride research from the perspective of its synthesis, integration and simulation from the material engineering aspects to applications in microelectronics industry.

Szu-Hua Chen
Blanka Magyari-Kope
Szuya Sandy Liao
Reviews03 Mar 2025
Nature Reviews Electrical Engineering

Volume: 2, P: 205-214
A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice

A common variant in the aldehyde dehydrogenase, ALDH2, which is enriched in East Asian populations can promote the risk of ventricular arrhythmia in mice exposed to a low alcohol dose emulating light alcohol consumption in humans.

An-Sheng Lee
Yen-Ling Sung
Shien-Fong Lin
ResearchOpen Access06 Jun 2023
Communications Biology

Volume: 6, P: 1-15
Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer

Yi-Ting Wang
Szu-Hua Pan
Yu-Ju Chen
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway

Mice deficient in Long-form collapsin response mediator protein-1 (LCRMP-1) show reduced fertility and perturbed F-actin cytoskeleton dynamics via the PI3K-Akt-mTOR axis.

Jung-Hsuan Chang
Chia-Hua Chou
Kang-Yi Su
ResearchOpen Access10 Apr 2023
Communications Biology

Volume: 6, P: 1-15

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