Nature Search

Cryo-EM structures of plant Augmin reveal coiled-coil assembly, antiparallel dimerization, and NEDD1 binding

Plant Augmin cryo-EM structures reveal a 40-nm hetero-octameric fork with coiled-coil interfaces, dual CH domains at V-junction switch for microtubule binding and NEDD1 β-propeller binding to the V-junction boosts anti-parallel Augmin dimerization, recruiting γ-TuRC for branch nucleation.

Md Ashaduzzaman
Aryan Taheri
Jawdat Al-Bassam
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-20
Crystal Structure of Glycyl-L-Alanine Hydrochloride

T. C. TRANTER
Research07 Jan 1956
Nature

Volume: 177, P: 37-38
Functional ultrasound neuroimaging reveals mesoscopic organization of saccades in the lateral intraparietal area

The functional organization of the posterior parietal cortex (PPC) for guiding eye movements has remained unknown. Here, the authors use functional ultrasound neuroimaging to reveal small, tuned clusters in PPC that reliably encode where we look over months to years.

Whitney S. Griggs
Sumner L. Norman
Richard A. Andersen
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-19
A search for human influences on the thermal structure of the atmosphere

B. D. Santer
K. E. Taylor
S. Tett
Research04 Jul 1996
Nature

Volume: 382, P: 39-46
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice

The management of ulcerative colitis (UC) remains challenging due to the complexity of its etiology. Here, the authors establish that argininosuccinate synthetase 1 (ASS1) and its metabolite arginine are pivotal inducers of UC, through the triggering of mTOR and iNOS activation, and the induction of gut microbiota dysbiosis by metabolomics and proteomics. Inhibition of ASS1 by C-01 provides a viable strategy for the treatment of UC.

Shijia Liu
Haijian Sun
Wei Zhou
ResearchOpen Access30 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens

A light-sheet microscope images large surgical and biopsy specimens non-destructively over large fields of view in two and three dimensions, with the same level of detail as traditional slide-based histopathology.

Adam K. Glaser
Nicholas P. Reder
Jonathan T. C. Liu
Research26 Jun 2017
Nature Biomedical Engineering

Volume: 1, P: 1-10
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Representation of internal speech by single neurons in human supramarginal gyrus

Wandelt et al. describe a brain–machine interface that captures intracortical neural activity during internal speech (words said within the mind with no associated movement or audio output) and translates those cortical signals into real-time text.

Sarah K. Wandelt
David A. Bjånes
Richard A. Andersen
ResearchOpen Access13 May 2024
Nature Human Behaviour

Volume: 8, P: 1136-1149
Mechanical instability at finite temperature

How do fluctuations alter the dynamics of phase transitions in crystal near a mechanical instability? To answer this question, here Mao et al. present a square lattice-based analytic model showing that large entropic effects can take place at nonzero temperature near the transition.

Xiaoming Mao
Anton Souslov
T. C. Lubensky
Research19 Jan 2015
Nature Communications

Volume: 6, P: 1-8
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

MSK-IMPACT is a clinical sequencing platform able to detect genomic mutations, copy number alterations and structural variants in a panel of cancer-related genes. This assay is implemented prospectively to inform patient enrollment in genomically matched clinical trials at Memorial Sloan Kettering Cancer Center (MSKCC). Sequencing results of tumor and matched normal tissue from a cohort of >10,000 patients with detailed clinical annotation provide an overview of the genomic landscape of advanced solid cancers and bring new insights into molecularly guided cancer therapy.

Ahmet Zehir
Ryma Benayed
Michael F Berger
Research08 May 2017
Nature Medicine

Volume: 23, P: 703-713
A simple technique to prevent retrograde ejaculation during assisted ejaculation

T C Lim
C Mallidis
H W G Baker
Research01 Mar 1994
Spinal Cord

Volume: 32, P: 142-149
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.

Yvonne Y Li
Grace T. Y. Chung
Kwok-Wai Lo
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-10
Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

Ye. O. Kazakov
J. Ongena
I. Zychor
Research19 Jun 2017
Nature Physics

Volume: 13, P: 973-978
Improved p-type conductivity in Al-rich AlGaN using multidimensional Mg-doped superlattices

T. C. Zheng
W. Lin
J. Y. Kang
ResearchOpen Access24 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

The bone microenvironment may alter therapeutic responses of disseminated breast cancer cells. Here the authors establish anex vivobone metastasis model, termed BICA, to delineate the effects of bone microenvironment and to rapidly discover anti-metastasis drugs.

Hai Wang
Lin Tian
Xiang H.-F. Zhang
ResearchOpen Access21 Apr 2017
Nature Communications

Volume: 8, P: 1-13
Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment

Bingwen Zhou
Qingrui Liu
Zhimin Fan
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-16
Superallowed Gamow–Teller decay of the doubly magic nucleus ¹⁰⁰Sn

Measurements of the half-life and decay energy of the β-decay of ¹⁰⁰Sn show that Gamow–Teller transitions of this nucleus have the greatest strength found so far and are ‘superallowed’.

C. B. Hinke
M. Böhmer
P. Strmeň
Research20 Jun 2012
Nature

Volume: 486, P: 341-345
Termini of calving glaciers as self-organized critical systems

Calving margins are highly sensitive to changes in climate and glacier terminus geometry. Numerical modelling suggests that calving glacier termini are self-organized critical systems that are fluctuating between states of advance and retreat.

J. A. Åström
D. Vallot
J. C. Moore
Research10 Nov 2014
Nature Geoscience

Volume: 7, P: 874-878
IUE observations of Solar System objects

A. L. Lane
E. Hamrick
C. A. Barth
News & Views01 Oct 1978
Nature

Volume: 275, P: 414-415
Molecular analysis of mutations and polymorphisms of the Lewis secretor type α(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation

J.-G. Chang
Y.-C. Ko
C.-T. Peng
Research01 Feb 2002
Journal of Human Genetics

Volume: 47, P: 60-65
Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape

Many RNAs become functional before their synthesis completes. Here the authors employ a single-molecule vectorial folding assay mimicking RNA transcription and show that the ZTP riboswitch is kinetically controlled and activated by slower unwinding and strategic pausing.

Boyang Hua
Christopher P. Jones
Taekjip Ha
ResearchOpen Access10 Sept 2020
Nature Communications

Volume: 11, P: 1-11
Dimensional crossover and band topology evolution in ultrathin semimetallic NiTe₂ films

Joseph A. Hlevyack
Liang-Ying Feng
T.-C. Chiang
ResearchOpen Access12 Apr 2021
npj 2D Materials and Applications

Volume: 5, P: 1-9
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Low Complexity Compression and Speed Enhancement for Optical Scanning Holography

P. W. M. Tsang
T.-C. Poon
Y. S. Kim
ResearchOpen Access06 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Decoding motor plans using a closed-loop ultrasonic brain–machine interface

Griggs, Norman et al. demonstrate a closed-loop ultrasound-based brain–machine interface (BMI) in rhesus macaques. The ultrasound BMI is capable of controlling eight independent movement directions and is stable across months without retraining.

Whitney S. Griggs
Sumner L. Norman
Richard A. Andersen
ResearchOpen Access30 Nov 2023
Nature Neuroscience

Volume: 27, P: 196-207
DNA vaccines for cervical cancer: from bench to bedside

Chien-Fu Hung
Archana Monie
T-C Wu
ReviewsOpen Access01 Dec 2007
Experimental & Molecular Medicine

Volume: 39, P: 679-689
Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

K-W Chang
T-C Lee
S-C Lin
ResearchOpen Access14 Sept 2004
British Journal of Cancer

Volume: 91, P: 1551-1555
Inferring causal molecular networks: empirical assessment through a community-based effort

The HPN-DREAM community challenge assessed the ability of computational methods to infer causal molecular networks, focusing specifically on the task of inferring causal protein signaling networks in cancer cell lines.

Steven M Hill
Laura M Heiser
Sach Mukherjee
ResearchOpen Access22 Feb 2016
Nature Methods

Volume: 13, P: 310-318
N⁶-methyladenosine (m⁶A) recruits and repels proteins to regulate mRNA homeostasis

A comprehensive proteomics screen for ‘reader’ proteins that recognize m⁶A-modified RNA reveals that the modification both promotes and prevents the binding of factors that control mRNA homeostasis in mammalian cells.

Raghu R Edupuganti
Simon Geiger
Michiel Vermeulen
Research04 Sept 2017
Nature Structural & Molecular Biology

Volume: 24, P: 870-878
Association between triglyceride to high-density lipoprotein cholesterol ratio and microalbuminuria in the Chinese population

Xue Zhang
Haofei Hu
Yongcheng He
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.

Pawel K. Mazur
Nicolas Reynoird
Or Gozani
Research21 May 2014
Nature

Volume: 510, P: 283-287
A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies

Timothy Nelson and colleagues present a transcriptome atlas of 40 key cell types from rice (Oryza sativa). The atlas reveals previously unrecognized cellular properties, and should serve as an essential resource for functional genomic analyses of rice and other plants.

Yuling Jiao
S Lori Tausta
Timothy Nelson
Research04 Jan 2009
Nature Genetics

Volume: 41, P: 258-263
A glimpse into chromatin remodeling

Chromatin remodelers are ATP-driven enzymes that can slide nucleosomes along DNA. Chen and colleagues present a tantalizing ∼4-Å view of the SWI/SNF ATPase motor bound to the nucleosome, which offers novel structural clues into the remodeling process.

Dale B Wigley
Gregory D Bowman
News & Views06 Jun 2017
Nature Structural & Molecular Biology

Volume: 24, P: 498-500
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

Ting-tao Liu
Xin Shi
Jian-gang Liu
ResearchOpen Access07 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-14
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group

D-C Liang
I-J Hung
K-S Lin
Research05 Feb 1999
Leukemia

Volume: 13, P: 155-160
Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues

J T-C Chang
C-T Liao
A-J Cheng
ResearchOpen Access23 May 2000
British Journal of Cancer

Volume: 82, P: 1946-1951
Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress

Viruses have been used for cancer treatment for over a century. From the early clinical studies with various wild-type viruses, to the modern trials with engineered viruses, virotherapy has emerged as a promising therapeutic strategy. The authors discuss the progress and challenges associated with oncolytic virotherapeutic agents, summarizing the data from clinical reports, and the implications of this data for future virotherapy development.

Ta-Chiang Liu
Evanthia Galanis
David Kirn
Reviews01 Feb 2007
Nature Clinical Practice Oncology

Volume: 4, P: 101-117
Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

J W Ho
S-c Choi
P C Sham
ResearchOpen Access21 Dec 2010
British Journal of Cancer

Volume: 104, P: 369-375
Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform

Timothy Liu
Ding Ren
Stephen T. C. Wong
ResearchOpen Access10 Dec 2013
Scientific Reports

Volume: 3, P: 1-10
Quantification of the binding potential of cell-surface receptors in fresh excised specimens via dual-probe modeling of SERS nanoparticles

Lagnojita Sinha
Yu Wang
Kenneth M. Tichauer
ResearchOpen Access26 Feb 2015
Scientific Reports

Volume: 5, P: 1-8
Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation

H K Roy
W J Karoski
T C Smyrk
ResearchOpen Access15 May 2001
British Journal of Cancer

Volume: 84, P: 1412-1416
Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer

C-Y Liu
C-H Wang
H-P Kuo
Research01 Aug 1998
British Journal of Cancer

Volume: 78, P: 534-541
Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent

Susanne Kossatz
Christian Brand
Thomas Reiner
ResearchOpen Access22 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy

Yu Wang
Soyoung Kang
Jonathan T.C. Liu
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Chromosomal, epigenetic and microRNA-mediated inactivation of LRP1B, a modulator of the extracellular environment of thyroid cancer cells

H Prazeres
J Torres
P Soares
Research08 Nov 2010
Oncogene

Volume: 30, P: 1302-1317
Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies

T-C Huang
B-S Ko
H-F Tien
Research20 Dec 2007
Leukemia

Volume: 22, P: 544-550
Dereplication of antimicrobial biosurfactants from marine bacteria using molecular networking

Albert D. Patiño
Manuela Montoya-Giraldo
Javier Gómez-León
ResearchOpen Access11 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Evaluation of screening for nasopharyngeal carcinoma: trial design using Markov chain models

H H Chen
T C Prevost
S W Duffy
ResearchOpen Access12 Mar 1999
British Journal of Cancer

Volume: 79, P: 1894-1900
Potent anti-tumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion

G Jiang
C-S Yang
Y-Q Liu
ResearchOpen Access08 Apr 2014
British Journal of Cancer

Volume: 110, P: 2496-2505

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