The mechanisms underlying fear extinction remain unclear. Here, the authors show that extinction enhances basolateral amygdala inputs about conditioned stimuli to intercalated cells, resulting in the inhibition of fear output central amygdala neurons. These changes required medial prefrontal activity during extinction training, but, once induced, could be expressed without prefrontal inputs.
- Taiju Amano
- Cagri T Unal
- Denis Paré
