Nuclear pore complexes (NPCs) serve as gateways between the nucleus and cytoplasm and allow only the transport of selected macromolecules across the nuclear envelope. NPCs are comprised of a scaffold that anchors proteins called FG-nucleoporins, which contain disordered regions that line the inner surface of the pore and extend into the lumen. This study reports the design of an artificial membrane that functions as a selective filter in allowing efficient passage of transport factors and transport factor carrying cargo that specifically bind to FG-nucleoporins.
- Tijana Jovanovic-Talisman
- Jaclyn Tetenbaum-Novatt
- Brian T. Chait
