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Showing 1–4 of 4 results
Advanced filters: Author: Tairan Yuwen Clear advanced filters

  • Studying the phase separation of small molecule systems provides a simplified framework for elucidating assembly pathways that may be obscured in macromolecular systems, but most studies focus on protein- or RNA-based condensates. Here, using nuclear magnetic resonance, the authors reveal that ATP, in the presence of Mg²⁺, undergoes phase separation coupled to percolation (PSCP), where the formation of 1:2 Mg²⁺–ATP nanoclusters precedes system-spanning networks and macroscopic condensation.

    • Zihan Li
    • Tairan Yuwen
    • Chun Tang
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-11

  • Small-amplitude overall motion of molecules in crystals limits the achievable resolution in X-ray diffraction, yet little is known about its exact nature. Here, the authors obtain NMR, XRD and MD data from three different crystal forms of a protein (ubiquitin) to gain insight into amplitude and timescale of such motions.

    • Peixiang Ma
    • Yi Xue
    • Paul Schanda
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • X-ray crystallography is the main method for protein structure determination. Here the authors combine solid-state NMR measurements and molecular dynamics simulations and show that crystal packing alters the thermodynamics and kinetics of local conformational exchange as well as overall rocking motion of protein molecules in the crystal lattice.

    • Vilius Kurauskas
    • Sergei A. Izmailov
    • Paul Schanda
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12