Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Talyn Chu Clear advanced filters

  • T cell exhaustion was thought to be strictly associated only with chronic infections and tumours, but it turns out that acute infections also generate a subset of precursor T cells with exhaustion-like phenotypes.

    • Talyn Chu
    • Ming Wu
    • Dietmar Zehn
    ResearchOpen Access
    Nature
    Volume: 640, P: 782-792

  • Here the authors show that dihydroorotate dehydrogenase in the de novo pyrimidine synthesis pathway functions as a cell fate checkpoint that can be targeted to specifically diminish the number and function of effector T cells without affecting the memory T cell pool and response to infection.

    • Stefanie Scherer
    • Susanne G. Oberle
    • Dietmar Zehn
    Research
    Nature Immunology
    Volume: 24, P: 501-515

  • In contrast with the classical dogma that the pathways generating either memory or ‘exhausted’ T cells are strictly segregated, data now identify a clonally distinct hybrid memory T cell subpopulation with an exhausted phenotype.

    • Talyn Chu
    • Jacqueline Berner
    • Dietmar Zehn
    News & Views
    Nature Immunology
    Volume: 21, P: 1484-1485