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A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects

Neuropathic pain is commonly treated with opioids due to limited alternatives. Here, authors determine cryo-EM structures of the neuronal glycine transporter GlyT2 and develop a reversible inhibitor that provides analgesia in vivo without side effects.

Ryan P. Cantwell Chater
Julian Peiser-Oliver
Azadeh Shahsavar
ResearchOpen Access16 Feb 2026
Nature Communications

P: 1-19
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829

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A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects

Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

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