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Advanced filters: Author: Tanshi Li Clear advanced filters

Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates

FcγRIIb captures its ligand and targets it to lysosomal degradation following endocytosis. Here authors design bispecific-antibody-like molecules they call FcγRIIb-targeting chimeras or FcRTACs, to capture antigens with one arm and degrade them via an FcγRIIb-binding second arm to promote the clearance of pathological protein aggregates.

Mingjuan Du
Na Li
Hongkai Zhang
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-20
High-throughput glycosylation screening method for biologics development using MALDI-TOF-MS

Glycosylation is a crucial quality attribute of therapeutic proteins, yet existing analytical methods struggle to meet rapid, high-throughput demands. Here, the authors present an optimized glycosylation analysis method using MALDI-TOF-MS, enabling high-throughput analysis with excellent precision and linearity.

Weilong Zhang
Liqi Xie
Shifang Ren
ResearchOpen Access02 Oct 2025
Communications Chemistry

Volume: 8, P: 1-9
Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72

Yan Zhao
Fengming Huang
Chengyu Jiang
ResearchOpen Access24 Mar 2022
Cellular & Molecular Immunology

Volume: 19, P: 702-714

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