Nature Search

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

E3 ubiquitin ligases are critical for innate and adaptive immunity. Cao and colleagues show that the E3 ubiquitin ligase Nrdp inhibits the production of proinflammatory cytokines while promoting the release of interferon-β in Toll-like receptor–triggered macrophages.

Chen Wang
Taoyong Chen
Xuetao Cao
Research31 May 2009
Nature Immunology

Volume: 10, P: 744-752
Publisher Correction: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8⁺ T cell activation

Mingjin Yang
Taoyong Chen
Xuetao Cao
Amendments and Corrections07 Feb 2020
Nature Immunology

Volume: 21, P: 355
Correction: Corrigendum: Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells

Minghui Zhang
Hua Tang
Xuetao Cao
Amendments and Corrections20 Oct 2014
Nature Immunology

Volume: 15, P: 1090
The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation

Cao and colleagues show that the RNA-binding E3 ligase MKRN2 selectively inhibits the translation of Il6 messenger RNA in activated macrophages.

Zhou Yu
Xuelian Li
Xuetao Cao
Research16 Jun 2025
Nature Immunology

Volume: 26, P: 1036-1047
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8⁺ T cell activation

The molecular details of the control of TCR signaling are still being determined. Cao and colleagues report that the E3 ligase Nrdp1 negatively regulates activity of the signaling kinase Zap70 selectively in CD8⁺ T cells.

Mingjin Yang
Taoyong Chen
Xuetao Cao
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1253-1262
RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase

Toll like receptors (TLRs) couple microbial sensing to initiation of immune responses, which are essential for defense against pathogens but may cause immunopathology when activated excessively. Here the authors show that RasGRP3 sets a threshold of TLR activation to prevent immunopathology.

Songqing Tang
Taoyong Chen
Jianli Wang
ResearchOpen Access14 Aug 2014
Nature Communications

Volume: 5, P: 1-14
A Large Scale Molecular Hessian Database for Optimizing Reactive Machine Learning Interatomic Potentials

Taoyong Cui
Yunhong Han
Qiyuan Zhao
ResearchOpen Access04 Dec 2025
Scientific Data

Volume: 13, P: 1-9
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells

Minghui Zhang
Hua Tang
Xuetao Cao
Research10 Oct 2004
Nature Immunology

Volume: 5, P: 1124-1133
De novo design of an intercellular signaling toolbox for multi-channel cell–cell communication and biological computation

Intercellular signalling is fundamental for the formation of complex structures from single cells. Here the authors design six orthogonal cell–cell signalling channels for cell consortia communication and bio-computation.

Pei Du
Huiwei Zhao
Chunbo Lou
ResearchOpen Access24 Aug 2020
Nature Communications

Volume: 11, P: 1-11
Extracellular calcium elicits feedforward regulation of the Toll-like receptor-triggered innate immune response

Songqing Tang
Taoyong Chen
Jianli Wang
Research17 Aug 2015
Cellular & Molecular Immunology

Volume: 14, P: 180-191
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis

Ha Zhu
Kun Chen
Xuetao Cao
ResearchOpen Access20 Jul 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH

Ranran Wang
Ying Shi
Xiang Wang
ResearchOpen Access11 Dec 2015
Scientific Reports

Volume: 5, P: 1-11
E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

Jiaying Huang
Zhou Yu
Xuetao Cao
ResearchOpen Access04 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-12
TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

Zhou Yu
Xuelian Li
Xuetao Cao
ResearchOpen Access28 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

Yao Long
Jiaxing Guo
Yongguang Tao
ResearchOpen Access01 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-15
PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma

Yating Liu
Lianlian Ouyang
Yongguang Tao
Research10 Jun 2022
Oncogene

Volume: 41, P: 3570-3583
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

Changqing Xie
Liang Zhong
Yongguang Tao
ResearchOpen Access20 Jun 2024
International Journal of Oral Science

Volume: 16, P: 1-14
Cancer progression is mediated by proline catabolism in non-small cell lung cancer

Yating Liu
Chao Mao
Yongguang Tao
Research07 Jan 2020
Oncogene

Volume: 39, P: 2358-2376
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

Bin Yan
Shuang Liu
Yongguang Tao
ResearchOpen Access30 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-15
Author Correction: GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

Yao Long
Jiaxing Guo
Yongguang Tao
Amendments and CorrectionsOpen Access30 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-2
Correction to: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Min Wang
Chao Mao
Bin Zhang
Amendments and Corrections05 Aug 2019
Cell Death & Differentiation

Volume: 27, P: 1447
The role of B cell immunity in lung adenocarcinoma

Long Shu
Tania Tao
Yongguang Tao
Reviews13 May 2025
Genes & Immunity

Volume: 26, P: 253-265
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Min Wang
Chao Mao
Bin Zhang
ResearchOpen Access20 Feb 2019
Cell Death & Differentiation

Volume: 26, P: 2329-2343
Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers

Shouping Liu
Weiwei Lai
Yongguang Tao
ResearchOpen Access03 Mar 2020
npj Precision Oncology

Volume: 4, P: 1-13
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties

Na Liu
Rui Yang
Yongguang Tao
ResearchOpen Access30 Sept 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-14
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor

Lianlian Ouyang
Bin Yan
Yongguang Tao
ResearchOpen Access17 Jun 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-14
GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3–mediated deubiquitination of LSH

Rui Yang
Na Liu
Yongguang Tao
Research15 Aug 2019
Oncogene

Volume: 38, P: 7133-7145
Neutrophil sensing of cytoplasmic, pathogenic DNA in a cGAS–STING-independent manner

Zhou Yu
Taoyong Chen
Xuetao Cao
Research Highlights27 Apr 2015
Cellular & Molecular Immunology

Volume: 13, P: 411-414
RNA editing by ADAR1 marks dsRNA as “self”

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

Zhou Yu
Taoyong Chen
Xuetao Cao
Research Highlights24 Nov 2015
Cell Research

Volume: 25, P: 1283-1284
Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8

Y Jiang
B Yan
Y Tao
Research09 Mar 2015
Oncogene

Volume: 34, P: 6079-6091
Lymphoid-specific helicase in epigenetics, DNA repair and cancer

Xiangyu Chen
Yamei Li
Yongguang Tao
Reviews07 Sept 2021
British Journal of Cancer

Volume: 126, P: 165-173
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Ziying Zhang
Haosheng Tang
Yongguang Tao
ReviewsOpen Access12 Oct 2019
Signal Transduction and Targeted Therapy

Volume: 4, P: 1-34
Regulating tumor suppressor genes: post-translational modifications

Ling Chen
Shuang Liu
Yongguang Tao
ReviewsOpen Access10 Jun 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-25

Search

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

Publisher Correction: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8⁺ T cell activation

Correction: Corrigendum: Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells

The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation

K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8⁺ T cell activation

RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase

A Large Scale Molecular Hessian Database for Optimizing Reactive Machine Learning Interatomic Potentials

Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells

De novo design of an intercellular signaling toolbox for multi-channel cell–cell communication and biological computation

Extracellular calcium elicits feedforward regulation of the Toll-like receptor-triggered innate immune response

RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis

The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH

E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO

GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

Cancer progression is mediated by proline catabolism in non-small cell lung cancer

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

Author Correction: GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

Correction to: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

The role of B cell immunity in lung adenocarcinoma

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers

The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties

The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor

GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3–mediated deubiquitination of LSH

Neutrophil sensing of cytoplasmic, pathogenic DNA in a cGAS–STING-independent manner

RNA editing by ADAR1 marks dsRNA as “self”

Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8

Lymphoid-specific helicase in epigenetics, DNA repair and cancer

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Regulating tumor suppressor genes: post-translational modifications

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