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Showing 1–12 of 12 results

Advanced filters: Author: Tara Chari Clear advanced filters

Monod: model-based discovery and integration through fitting stochastic transcriptional dynamics to single-cell sequencing data

Monod fits biophysically motivated models to single-cell transcriptomics data, empowering multifaceted and integrative insights of gene expression dynamics, stochasticity and regulation.

Gennady Gorin
Tara Chari
Lior Pachter
Research07 Nov 2025
Nature Methods

Volume: 22, P: 2286-2300
Detection of viral sequences at single-cell resolution identifies novel viruses associated with host gene expression changes

A workflow using conserved amino acid domains identifies viruses in sequence data at single-cell resolution.

Laura Luebbert
Delaney K. Sullivan
Lior Pachter
Research22 Apr 2025
Nature Biotechnology

Volume: 44, P: 100-109
Biophysically interpretable inference of cell types from multimodal sequencing data

MeK-means clusters single-cell multimodal data by linking modalities through their biophysical relationships. We redefine clusters through transcription kinetics to reveal how RNA production and processing drive cellular diversity and disease.

Tara Chari
Gennady Gorin
Lior Pachter
Research20 Sept 2024
Nature Computational Science

Volume: 4, P: 677-689
Genome organization around nuclear speckles drives mRNA splicing efficiency

Nuclear speckles are shown to have a functional role in mRNA splicing, whereby dynamic three-dimensional organization of DNA around these structures mediates splicing efficiency.

Prashant Bhat
Amy Chow
Mitchell Guttman
Research08 May 2024
Nature

Volume: 629, P: 1165-1173
Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data

biVI models the biophysical processes generating nascent and mature single-cell transcriptomes using variational autoencoders.

Maria Carilli
Gennady Gorin
Lior Pachter
Research25 Jul 2024
Nature Methods

Volume: 21, P: 1466-1469
Author Correction: The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring

Hani J. Marcus
Pedro T. Ramirez
Arsenio Paez
Amendments and Corrections31 Jan 2024
Nature Medicine

Volume: 30, P: 1213
Correction: GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review

Paula Rodriguez-Otero
Niels W. C. J. van de Donk
Ajai Chari
Amendments and CorrectionsOpen Access06 Mar 2024
Blood Cancer Journal

Volume: 14, P: 1
Ixazomib, lenalidomide and dexamethasone consolidation with randomized ixazomib or lenalidomide maintenance after autologous transplant in newly diagnosed multiple myeloma

Michael Slade
Thomas G. Martin
Ravi Vij
Research16 Sept 2022
Leukemia

Volume: 36, P: 2917-2921
The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring

To guide the safe implementation of the next generation of surgical robots, the IDEAL Robotics Colloquium provides recommendations for their evaluation throughout the product life cycle—considering multiple perspectives within and beyond the surgical team.

Hani J. Marcus
Pedro T. Ramirez
Arsenio Paez
Reviews19 Jan 2024
Nature Medicine

Volume: 30, P: 61-75
Daratumumab, lenalidomide, and dexamethasone in relapsed/refractory myeloma: a cytogenetic subgroup analysis of POLLUX

Jonathan L. Kaufman
Meletios A. Dimopoulos
Jesus San-Miguel
ResearchOpen Access03 Nov 2020
Blood Cancer Journal

Volume: 10, P: 1-10
MicroRNAs in extracellular vesicles: potential cancer biomarkers

Takashi Kinoshita
Kenneth W Yip
Fei-Fei Liu
Reviews07 Jul 2016
Journal of Human Genetics

Volume: 62, P: 67-74
GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review

Paula Rodriguez-Otero
Niels W. C. J. van de Donk
Ajai Chari
ReviewsOpen Access02 Feb 2024
Blood Cancer Journal

Volume: 14, P: 1-13