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Showing 1–10 of 10 results
Advanced filters: Author: Taralynn M. Mack Clear advanced filters

  • Results from integrative population-based investigations indicate co-occurring types of clonal hematopoiesis are highly enriched and markedly increase blood cancer risk, highlighting new opportunities for early detection and targeted surveillance of high-risk individuals.

    • Kara M. Barnao
    • Aubrey K. Hubbard
    • Mitchell J. Machiela
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • Here, the authors use passenger mutations to quantify expansion rate in ~6,000 people with mosaic chromosomal alterations in the NHLBI TOPMed cohort, finding associations between growth rate and blood counts along with germline genetic modulators of growth rate.

    • Yash Pershad
    • Taralynn Mack
    • Alexander G. Bick
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Exploring the clonal expansion of somatically mutated hematopoietic stem cells with aging, Mack, Raddatz et al. quantify rates of clonal expansion in 4,370 individuals in the Trans-Omics for Precision Medicine cohort, observing epigenetic and proteomic patterns associated with clonal hematopoiesis of indeterminate potential.

    • Taralynn M. Mack
    • Michael A. Raddatz
    • Alexander G. Bick
    Research
    Nature Aging
    Volume: 4, P: 1043-1052

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763

  • The relationship between pathogenic germline variation, clonal hematopoiesis (CH) and risk of hematologic malignancy is explored in 731,835 individuals across 6 cohorts. Carriers of variants in certain genes show distinct patterns of CH and increased risk of CH progression to malignancy.

    • Jie Liu
    • Duc Tran
    • Kelly L. Bolton
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1872-1880

  • The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

    • Tim H. H. Coorens
    • Ji Won Oh
    • Yuqing Wang
    Reviews
    Nature
    Volume: 643, P: 47-59