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Showing 1–2 of 2 results
Advanced filters: Author: Tek Hong Chung Clear advanced filters

  • Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartments and single RNA molecules, revealing early defects in ALS-linked mutant C9orf72 transcripts.

    • Karen Yap
    • Tek Hong Chung
    • Eugene V. Makeyev
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Here, the reaction of the suicide inhibitor sulbactam with the M. tuberculosis β-lactamase (BlaC) is investigated with time-resolved crystallography. Singular Value Decomposition is implemented to extract kinetic information despite changes in unit cell parameters during the time-course of the reaction.

    • Tek Narsingh Malla
    • Kara Zielinski
    • Marius Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15