Pulmonary veno-occlusive disease (PVOD) is a fatal disease characterised by remodelling of pulmonary veins and haemosiderin accumulation in macrophages. Here the authors examine the lack of GCN2 in PVOD as this has been observed in human disease and deficiency of GCN2 in mouse and rat PVOD models alters transcriptome profiles and increases macrophage ferroptosis.
- Jingyuan Zhang
- Pei Mao
- Jun Yang
