N-terminal acetylases catalyze the cotranslational modification of myriad proteins. Structural and mutational analyses of the NatA complex, comprising a catalytic and auxiliary subunit, and of the catalytic subunit alone reveal the molecular basis for substrate binding, specificity and mode of catalysis, and the role of the auxiliary subunit in these activities.
- Glen Liszczak
- Jacob M Goldberg
- Ronen Marmorstein
