Nature Search

All-optical visualization of specific molecules in the ultrastructural context of brain tissue

Pan-expansion microscopy of tissue combines staining of proteins and lipids with immunolabeling.

Ons M’Saad
Allison Cairns
Joerg Bewersdorf
ResearchOpen Access26 Nov 2025
Nature Biotechnology

P: 1-15
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Emmanuel J. H. J. Wiertz
Domenico Tortorella
Hidde L. Ploegh
Research05 Dec 1996
Nature

Volume: 384, P: 432-438
Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice.

Karen Perez de Arce
Adema Ribic
Thomas Biederer
ResearchOpen Access28 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Synaptic uSIRPation: the active neuron reigns over presynaptic partners

A study reveals that SIRPα is released from postsynaptic neurons to induce and mature their synaptic inputs, using CD47 as the presynaptic receptor. SIRPα is cleaved in an activity-dependent manner to act as retrograde signal.

Thomas Biederer
News & Views25 Sept 2013
Nature Neuroscience

Volume: 16, P: 1361-1362
The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior

Joanna I Giza
Yonwoo Jung
Thomas Biederer
Research21 Nov 2012
Neuropsychopharmacology

Volume: 38, P: 628-638
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
A compendium of human gene functions derived from evolutionary modelling

Evolutionary modelling and expert review are applied to integrate experimentally supported knowledge accumulated in the Gene Ontology knowledgebase to create a draft human gene ‘functionome’.

Marc Feuermann
Huaiyu Mi
Paul D. Thomas
ResearchOpen Access26 Feb 2025
Nature

Volume: 640, P: 146-154
Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution

The combination of adaptive optics with an improved isoSTED nanoscope allows imaging of cells and tissues with sub-50-nm isotropic resolution.

Xiang Hao
Edward S. Allgeyer
Joerg Bewersdorf
Research31 May 2021
Nature Methods

Volume: 18, P: 688-693
A synaptomic analysis reveals dopamine hub synapses in the mouse striatum

The neurotransmitter dopamine is an important regulator of brain function. Here the authors describe “dopamine hub synapses”, where dopamine transmission may act in synergy with other neurotransmitters.

Vincent Paget-Blanc
Marlene E. Pfeffer
Etienne Herzog
ResearchOpen Access03 Jun 2022
Nature Communications

Volume: 13, P: 1-19
Hooking up new synapses

Synapse formation requires adhesive interactions between pre- and postsynaptic membranes. A new study reports that netrin-G2 ligand (NGL-2) interactions with netrin-G2 induces excitatory synapses, expanding the range of known synapse-inducing signals.

Thomas Biederer
News & Views01 Oct 2006
Nature Neuroscience

Volume: 9, P: 1203-1204
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa

Retinitis pigmentosa is an inherited form of blindness caused by the progressive loss of rod and cone photoreceptors. Here, Guo et al.show that expression of a short amino-terminal domain of the histone deacetylase HDAC4 prolongs cone survival in mouse models, helping to partially restore vision.

Xinzheng Guo
Shao-Bin Wang
Bo Chen
Research14 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy

Iterative expansion microscopy enables the use of confocal microscopes to uncover nanostructures in expanded yet otherwise intact tissues at a resolution of about 20 nm, as shown with the imaging of periodic amyloid nanoclusters in brain tissue.

Deblina Sarkar
Jinyoung Kang
Edward S. Boyden
Research29 Aug 2022
Nature Biomedical Engineering

Volume: 6, P: 1057-1073
Mixed-culture assays for analyzing neuronal synapse formation

Thomas Biederer
Peter Scheiffele
Protocols29 Mar 2007
Nature Protocols

Volume: 2, P: 670-676
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Sandra Sanchez-Roige
Mariela V. Jennings
Abraham A. Palmer
ResearchOpen Access12 May 2023
Translational Psychiatry

Volume: 13, P: 1-11
Structural analyses of FERM domain-mediated membrane localization of FARP1

Yi-Chun Kuo
Xiaojing He
Xuewu Zhang
ResearchOpen Access11 Jul 2018
Scientific Reports

Volume: 8, P: 1-10

Search

All-optical visualization of specific molecules in the ultrastructural context of brain tissue

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Synaptic uSIRPation: the active neuron reigns over presynaptic partners

The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A compendium of human gene functions derived from evolutionary modelling

Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution

A synaptomic analysis reveals dopamine hub synapses in the mouse striatum

Hooking up new synapses

A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa

Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy

Mixed-culture assays for analyzing neuronal synapse formation

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Structural analyses of FERM domain-mediated membrane localization of FARP1

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