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Showing 1–21 of 21 results
Advanced filters: Author: Thomas Boesen Clear advanced filters

  • The crystal structures and cryo-electron microscopy reconstructions of eEF3 on its own and attached to the ribosome are resolved, providing an insight into how eEF3 functions as a translation factor on the A and E sites on a ribosome.

    • Christian B. F. Andersen
    • Thomas Becker
    • Roland Beckmann
    Research
    Nature
    Volume: 443, P: 663-668

  • This work reveals how a regulatory domain in O-GlcNAc hydrolase (OGA) shapes enzyme flexibility and activity, uncovering mechanisms that help maintain O-GlcNAc balance in cells.

    • Sara Basse Hansen
    • Sergio G. Bartual
    • Daan M. F. van Aalten
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Tetrahydrocannabinol (THC) analogs target the cannabinoid receptor CB1 for therapeutic and psychoactive effects. Here, the authors determine spatiotemporal ligand interactions critical for potency, efficacy, off-rates and drug design.

    • Thor S. Thorsen
    • Yashraj Kulkarni
    • David E. Gloriam
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • CD163, a macrophage receptor, is essential for clearing hemoglobin during hemolysis to prevent oxidative damage. Here, the authors reveal the cryo-electron microscopy structure of CD163 bound to haptoglobin-hemoglobin, uncovering calcium-dependent interactions critical for its function and oligomerization.

    • Anders Etzerodt
    • Jakob Hauge Mikkelsen
    • Christian Brix Folsted Andersen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT transport cycle.

    • Kamil Gotfryd
    • Thomas Boesen
    • Ulrik Gether
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Zinc acts as a second messenger in root nodules and regulates nitrogen homeostasis by controlling the transition between the active state and the inactive filamentous state of the novel transcriptional regulator FIXATION UNDER NITRATE (FUN).

    • Jieshun Lin
    • Peter K. Bjørk
    • Dugald Reid
    ResearchOpen Access
    Nature
    Volume: 631, P: 164-169

  • Here, authors analyse the structural organisation of the large carbon-phosphorus lyase enzyme from bacteria using electron microscopy and discover that it contains two ATP-binding cassette dimers of PhnK and PhnL and opens upon ATP hydrolysis.

    • Søren K. Amstrup
    • Sui Ching Ong
    • Ditlev E. Brodersen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Cryo-EM structures of the yeast P4-ATPase Drs2p–Cdc50p in three different states of activation provide insights into the function of this lipid flippase, including mechanisms of autoinhibition and PI4P-dependent activation.

    • Milena Timcenko
    • Joseph A. Lyons
    • Poul Nissen
    Research
    Nature
    Volume: 571, P: 366-370

  • Bacterial fuel cells have generated attention with the prospect of green energy production; current research is focused on optimising the system to improve efficiency. Here, the authors report on the feeding of carbon dots to S. oneidensis MR-1 to enhance metabolic activity and bioelectric generation.

    • Chenhui Yang
    • Hüsnü Aslan
    • Miao Yu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • By using a combined computational and experimental approach, peptide exchange of 12 abundant MHC-II allotypes is shown to maintain responsiveness to HLA-DM catalysis. HLA-DM susceptibility is postulated to contribute to disease association.

    • Esam T. Abualrous
    • Sebastian Stolzenberg
    • Christian Freund
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1196-1204

  • RNA nanostructures can be designed to fold during transcription, but the solution structure has remained elusive. Here the authors use cryogenic electron microscopy to determine the structure of a panel of RNA origami shapes and uncover the design and folding principles.

    • Ewan K. S. McRae
    • Helena Østergaard Rasmussen
    • Ebbe Sloth Andersen
    Research
    Nature Nanotechnology
    Volume: 18, P: 808-817

  • Ice-nucleating proteins promote ice formation at high sub-zero temperatures, but the mechanism is still unclear. The authors investigate a model ice-nucleating protein at the air-water interface using vibrational sum frequency generation spectroscopy and simulations, revealing its reorientation at low temperatures, which increases contact with water molecules and promotes their ordering.

    • Steven J. Roeters
    • Thaddeus W. Golbek
    • Tobias Weidner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show that a Leu residue occupies the empty substrate site and is essential for function.

    • Lina Malinauskaite
    • Saida Said
    • Poul Nissen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • Extracellular electron transport in Geobacter has long been ascribed to conductive pili. Cryogenic electron microscopy now reveals non-conductive filaments made of pilin-heterodimer subunits. The combined data support a role for Geobacter pili in cytochrome-nanowire secretion instead of conduction.

    • Thomas Boesen
    • Lars Peter Nielsen
    • Andreas Schramm
    News & Views
    Nature Microbiology
    Volume: 6, P: 1347-1348