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Showing 1–3 of 3 results
Advanced filters: Author: Thomas Gensollen Clear advanced filters

  • How early-life intestinal microenvironment shape colonic iNKT cell development to be further explored. The authors here identify an early-life enriched Wnt4+ stromal cells form a microbiota-regulated neonatal niche that drives iNKT expansion via BMP2-MAPK signaling and programs long term mucosal immune homeostasis.

    • Xi Lin
    • Chloe Hyun-Jung Lee
    • Richard S. Blumberg
    ResearchOpen Access
    Nature Communications
    P: 1-22

  • Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell–mediated anti-tumor immunity.

    • Mark A. Exley
    • Thomas Gensollen
    • Richard S. Blumberg
    News & Views
    Nature Cancer
    Volume: 1, P: 1032-1034