Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–19 of 19 results
Advanced filters: Author: Thomas Knöpfel Clear advanced filters

  • Our understanding of neuronal circuit function has benefitted from methods that allow the activity of individual cells and populations of neurons to be monitored. Thomas Knöpfel reviews recent advances in the technology of genetically encoded indicators of neural activity, which are enabling circuits to be examined in an increasingly sophisticated manner.

    • Thomas Knöpfel
    Reviews
    Nature Reviews Neuroscience
    Volume: 13, P: 687-700

  • Optogenetics has already had a major impact on neuroscience research, particularly in the study of cognitive and emotional processes. Here, Song and Knöpfel discuss emerging applications of optogenetic technologies, focusing on their potential to transform neuroscience drug discovery programmes and to provide novel therapeutic approaches for conditions such as Parkinson disease, mood disorders and epilepsy.

    • Chenchen Song
    • Thomas Knöpfel
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 97-109

  • The cerebral cortex has ongoing electrical activities with rich and complex patterns in space and time. Here, the authors use optical voltage imaging in mice and computational methods, relating these complexities to different levels of wakefulness.

    • Yuqi Liang
    • Junhao Liang
    • Changsong Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Genetically encoded voltage-sensitive fluorescent proteins can be used to measure electrical activity from selected populations of neurons. This study demonstrates that these probes, when expressed in pyramidal cells of mouse somatosensory cortex, can report electrical responses in vivo. These proteins are a complementary tool to calcium imaging techniques for optical functional brain imaging.

    • Walther Akemann
    • Hiroki Mutoh
    • Thomas Knöpfel
    Research
    Nature Methods
    Volume: 7, P: 643-649

  • Using temperature-sensitive ion channels and magnetic nanoparticles attached to membranes of cells, the electrical activity in neurons can be controlled by an externally applied magnetic field.

    • Thomas Knöpfel
    • Walther Akemann
    News & Views
    Nature Nanotechnology
    Volume: 5, P: 560-561

  • Advances in methods that allow targeted remote control of neuronal activity open new possibilities for investigating and manipulating the function of neuronal circuits in vivo.

    • Thomas Knöpfel
    News & Views
    Nature Methods
    Volume: 5, P: 293-295

  • Sensory stimuli usually arrive simultaneously but the neural-circuit mechanisms that combine multiple streams of sensory information are incompletely understood. The authors here show that visual-auditory pairing drives plasticity in multi-modal neuron networks within the mouse visual cortex.

    • Thomas Knöpfel
    • Yann Sweeney
    • Samuel J. Barnes
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.

    • Raziye Karapinar
    • Jan Claudius Schwitalla
    • Stefan Herlitze
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Genetically encoded voltage indicators (GEVIs) are emerging tools to elucidate the inner workings of the brain. In this Review, Knopfel and Song outline the potentials of GEVI imaging based on recent neurotechnological and conceptual advances in the brain sciences.

    • Thomas Knöpfel
    • Chenchen Song
    Reviews
    Nature Reviews Neuroscience
    Volume: 20, P: 719-727

  • The properties and location of synaptic integrins put them in an ideal position to transduce signals from the extracellular matrix to intracellular signalling pathways. Park and Goda, here, describe the mechanisms underlying integrin-mediated synapse regulation and its contributions to development, plasticity and disease.

    • Yun Kyung Park
    • Yukiko Goda
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 745-756

  • Prospects for new applications in quantum simulations, spectroscopic precision measurements and very low temperature physics and chemistry have resulted in significant advances in the study of cold molecules, with their trapping for long times remaining a major challenge. The authors present an experiment in which polar molecular radicals produced by Stark deceleration are magnetically trapped for a time of order 20 s providing an improvement of up to two orders of magnitude over room temperature experiments.

    • Dominik Haas
    • Claudio von Planta
    • Stefan Willitsch
    ResearchOpen Access
    Communications Physics
    Volume: 2, P: 1-7