Nature Search

Mitochondrial fission requires DRP1 but not dynamins

Tiago Branco Fonseca
Ángela Sánchez-Guerrero
Nuno Raimundo
Research19 Jun 2019
Nature

Volume: 570, P: E34-E42
A cortico-collicular circuit for orienting to shelter during escape

The retrosplenial cortex and superior colliculus of mouse form a neural circuit that specifically encodes shelter location, facilitating rapid escape from predatory threats.

Dario Campagner
Ruben Vale
Tiago Branco
Research21 Dec 2022
Nature

Volume: 613, P: 111-119
The probability of neurotransmitter release: variability and feedback control at single synapses

Two neurons can be connected by multiple synaptic contacts with different likelihoods of neurotransmitter release. Branco and staras discuss the role of feedback regulation from the postsynaptic site in determining this probability at individual synapses and consider the possible functional advantages of variable neurotransmitter release.

Tiago Branco
Kevin Staras
Reviews01 May 2009
Nature Reviews Neuroscience

Volume: 10, P: 373-383
Mice learn multi-step routes by memorizing subgoal locations

Shamash et al. examine how mice learn to get past an obstacle blocking their path to a goal. They found that mice instinctively adopt a subgoal memory strategy, which combines elements from both habitual learning and the cognitive map theory.

Philip Shamash
Sarah F. Olesen
Tiago Branco
Research29 Jul 2021
Nature Neuroscience

Volume: 24, P: 1270-1279
Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Ana Margarida Pinto
Rinie Geenen
José A. P. da Silva
Correspondence24 Mar 2023
Nature Reviews Rheumatology

Volume: 19, P: 322-323
Reply to ‘Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?’

Ana Margarida Pinto
Rinie Geenen
José A. P. da Silva
Correspondence23 Mar 2023
Nature Reviews Rheumatology

Volume: 19, P: 319-320
Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region

Genomic and epidemiologic analyses revealed that a novel reassortant viral lineage of the Oropouche virus, which has been circulating in the western Amazon region of Brazil for about a decade, is associated with the recent human outbreaks between 2022 and 2024.

Felipe Gomes Naveca
Tatiana Amaral Pires de Almeida
Gonzalo Bello
Research18 Sept 2024
Nature Medicine

Volume: 30, P: 3509-3521
The site of action potential initiation in cerebellar Purkinje neurons

Beverley A Clark
Pablo Monsivais
Michael Häusser
Research23 Jan 2005
Nature Neuroscience

Volume: 8, P: 137-139
Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid

Stem cell models of organogenesis are a valuable tool for the study of human development, but often lack the context of tissue-tissue interaction. Here they generate human multi-lineage organoids comprising pro-epicardium, septum transversum, and liver bud, which they co-culture with heart organoids to generate a physiologically relevant model of organogenesis.

Mariana A. Branco
Tiago P. Dias
Maria Margarida Diogo
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-18
The influence of attachments on the adaptability and quality of life of patients using Invisalign

Janaina Menegussi
Karina Maria Salvatore Freitas
Paula Cotrin
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
How the brain plays musical statues

Activating a specific subpopulation of glutamatergic neurons in the brainstem issues a motor command for global motor arrest. This motor arrest is distinct from defensive freezing and has a striking pause-and-play pattern accompanied by a reduction in respiration and heart rate.

Yaara Lefler
Tiago Branco
News & Views07 Aug 2023
Nature Neuroscience

Volume: 26, P: 1482-1484
Extrasynaptic vesicle recycling in mature hippocampal neurons

In the classical model, fast neuronal signalling occurs at specialized presynaptic terminals. Now, Ratnayakaet al. show that stimulus-driven fusion and recycling of synaptic vesicles can occur at axonal sites remote from conventional synapses. These findings have implications for dynamic forms of neuron–neuron communication.

Arjuna Ratnayaka
Vincenzo Marra
Kevin Staras
ResearchOpen Access08 Nov 2011
Nature Communications

Volume: 2, P: 1-11
A synaptic threshold mechanism for computing escape decisions

In the midbrain defensive circuit, the decision to escape is computed by an unreliable synaptic connection that thresholds threat information integrated in the medial superior colliculus, and controls activation of dorsal periaqueductal grey neurons.

Dominic A. Evans
A. Vanessa Stempel
Tiago Branco
Research20 Jun 2018
Nature

Volume: 558, P: 590-594
Prefrontal cortical control of a brainstem social behavior circuit

The authors describe cortical projections mediating the modulation of social behavior. Neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray play a critical role in the behavioral adaptation to social defeat in mice.

Tamara B Franklin
Bianca A Silva
Cornelius T Gross
Research09 Jan 2017
Nature Neuroscience

Volume: 20, P: 260-270
Active dendritic integration as a mechanism for robust and precise grid cell firing

Combining electrophysiology and computational modeling, the authors show that the dendrites of entorhinal cortex stellate and pyramidal cells are electrically excitable and that this improves the robustness of grid cell firing. The results suggest that active dendrites are critical for spatial navigation, a fundamental computation in the brain.

Christoph Schmidt-Hieber
Gabija Toleikyte
Michael Häusser
Research19 Jun 2017
Nature Neuroscience

Volume: 20, P: 1114-1121
Global disparities in SARS-CoV-2 genomic surveillance

In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

Anderson F. Brito
Elizaveta Semenova
Nuno R. Faria
ResearchOpen Access16 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia

In this Perspective, the authors propose a model in which an imbalance of threat and soothing systems leads to hyperactivation of the brain’s salience network, which, in conjunction with other mechanisms, contributes to fibromyalgia.

Ana Margarida Pinto
Rinie Geenen
José A. P. da Silva
Reviews05 Dec 2022
Nature Reviews Rheumatology

Volume: 19, P: 44-60
West Nile virus transmission potential in Portugal

Lourenço et al. review historical data and quantify the transmission potential of West Nile virus in Portugal. They report a North-South divide in infection patterns, a higher ecological capacity in the south, and an increasing positive effect of climate change over the last 40 years.

José Lourenço
Sílvia C. Barros
Uri Obolski
ResearchOpen Access10 Jan 2022
Communications Biology

Volume: 5, P: 1-12
Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

Neuronal dendrites are not passive cables, but whether their excitability contributes to computation at the cell’s soma has been uncertain; by observing and interfering with dendritic ‘spikes’ during sensory stimulation, it is now shown that active dendritic processing enhances somatic orientation selectivity, a fundamental brain computation.

Spencer L. Smith
Ikuko T. Smith
Michael Häusser
Research27 Oct 2013
Nature

Volume: 503, P: 115-120
Large Scale Genome-Centric Metagenomic Data from the Gut Microbiome of Food-Producing Animals and Humans

Leandro Nascimento Lemos
Fabíola Marques de Carvalho
Ana Tereza Ribeiro de Vasconcelos
ResearchOpen Access25 Jun 2022
Scientific Data

Volume: 9, P: 1-7
A community resource for paired genomic and metabolomic data mining

Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

Michelle A. Schorn
Stefan Verhoeven
Justin J. J. van der Hooft
Comments & OpinionOpen Access15 Feb 2021
Nature Chemical Biology

Volume: 17, P: 363-368
Accurate determination of marker location within whole-brain microscopy images

Adam L. Tyson
Mateo Vélez-Fort
Troy W. Margrie
ResearchOpen Access18 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
Direct tissue-sensing reprograms TLR4⁺ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4⁺ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.

Daniela Amaral-Silva
Rute Gonçalves
Helena Soares
ResearchOpen Access27 Sept 2021
Communications Biology

Volume: 4, P: 1-16
SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Borges et al. study the dynamics of SARS-CoV-2 in Portugal during 2020. The authors use phylodynamic modelling to infer patterns of SARS-CoV-2 introduction into Portugal and its subsequent spread, providing a comprehensive genomic epidemiology study of the early SARS-CoV-2 epidemic in Portugal.

Vítor Borges
Joana Isidro
João Paulo Gomes
ResearchOpen Access28 Jan 2022
Communications Medicine

Volume: 2, P: 1-11
Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture

Mariana A. Branco
João P. Cotovio
Maria Margarida Diogo
ResearchOpen Access25 Jun 2019
Scientific Reports

Volume: 9, P: 1-13
Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Carina de Lima Buzzo
Tiago Medina
Karina R. Bortoluci
ResearchOpen Access02 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

Tiago Rodrigues
Paulo Matafome
Raquel Seiça
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-13
Glycation potentiates neurodegeneration in models of Huntington’s disease

Hugo Vicente Miranda
Marcos António Gomes
Tiago Fleming Outeiro
ResearchOpen Access18 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
A database of freshwater fish species of the Amazon Basin

Céline Jézéquel
Pablo A. Tedesco
Thierry Oberdorff
ResearchOpen Access19 Mar 2020
Scientific Data

Volume: 7, P: 1-9
A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

Samuel Challéat
Nicolas Farrugia
Vera Zina
ResearchOpen Access27 Aug 2024
Scientific Data

Volume: 11, P: 1-16

Search

Mitochondrial fission requires DRP1 but not dynamins

A cortico-collicular circuit for orienting to shelter during escape

The probability of neurotransmitter release: variability and feedback control at single synapses

Mice learn multi-step routes by memorizing subgoal locations

Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia

Reply to ‘Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?’

Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region

The site of action potential initiation in cerebellar Purkinje neurons

Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid

The influence of attachments on the adaptability and quality of life of patients using Invisalign

How the brain plays musical statues

Extrasynaptic vesicle recycling in mature hippocampal neurons

A synaptic threshold mechanism for computing escape decisions

Prefrontal cortical control of a brainstem social behavior circuit

Active dendritic integration as a mechanism for robust and precise grid cell firing

Global disparities in SARS-CoV-2 genomic surveillance

Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia

West Nile virus transmission potential in Portugal

Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

Large Scale Genome-Centric Metagenomic Data from the Gut Microbiome of Food-Producing Animals and Humans

A community resource for paired genomic and metabolomic data mining

Accurate determination of marker location within whole-brain microscopy images

Direct tissue-sensing reprograms TLR4⁺ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

Glycation potentiates neurodegeneration in models of Huntington’s disease

A database of freshwater fish species of the Amazon Basin

A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

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