Nature Search

Mendelian randomization study of GLP-1R effects on ovarian cancer subtypes mediated by metabolic factors

Liu, Chen, Yang et al. investigate the effect of GLP-1 receptor activation on ovarian cancer risk across different subtypes. They show that it specifically lowers the risk of one subtype, endometrioid ovarian cancer, mediated in part by specific metabolic factors.

Jiajia Liu
Zhihe Chen
Jie Zheng
ResearchOpen Access12 Jan 2026
Communications Medicine

P: 1-13
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health

Insulin resistance contributes to cardiometabolic disease, but its genetic basis remains incompletely defined. Here, the authors identify 217 associated loci and highlight potential therapeutic targets, linking insulin resistance to multiple diseases and aging traits.

Chaojie Ye
Chun Dou
Tiange Wang
ResearchOpen Access17 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

Tiange Wang
Zhun Shi
Weiqing Wang
Research06 Jun 2024
Nature Medicine

Volume: 30, P: 1722-1731
Transcriptome-wide Mendelian randomization during CD4⁺ T cell activation reveals immune-related drug targets for cardiometabolic diseases

Here, the authors identify genes and drug targets that show immune cell-specific and activation time point-specific effects on type 2 diabetes and coronary heart disease and find strong immune-to-metabolic disease connections.

Xueyan Wu
Hui Ying
Jieli Lu
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Mendelian randomization evidence for the causal effect of mental well-being on healthy aging

Ye et al. find a positive causal effect of mental well-being on healthy aging, independent of socioeconomic status. This work underscores the imperative to prioritize mental well-being in health policies geared to fostering healthy aging.

Chao-Jie Ye
Dong Liu
Tian-Ge Wang
Research17 Jun 2024
Nature Human Behaviour

Volume: 8, P: 1798-1809
Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans

The authors used Mendelian randomization to investigate how various dimensions of socio-economic status causally affect longevity. They found a positive independent causal effect of education on longevity but no evidence for independent effects from income or occupation.

Chao-Jie Ye
Li-Jie Kong
Tian-Ge Wang
Research29 Jun 2023
Nature Human Behaviour

Volume: 7, P: 1357-1370
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals

Yanan Cao
Lin Li
Mengyao Wang
ResearchOpen Access30 Apr 2020
Cell Research

Volume: 30, P: 717-731
Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function

Xueyan Wu
Lei Jiang
Jieli Lu
ResearchOpen Access05 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
Dilute carbon in H₃S under pressure

Xiaoyu Wang
Tiange Bi
Eva Zurek
ResearchOpen Access27 Apr 2022
npj Computational Materials

Volume: 8, P: 1-9
Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

Jia Xu
Hou Yanan
Chen Yuhong
ResearchOpen Access02 Apr 2019
Scientific Reports

Volume: 9, P: 1-9

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Mendelian randomization study of GLP-1R effects on ovarian cancer subtypes mediated by metabolic factors

Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health

Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk

Transcriptome-wide Mendelian randomization during CD4⁺ T cell activation reveals immune-related drug targets for cardiometabolic diseases

Mendelian randomization evidence for the causal effect of mental well-being on healthy aging

Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans

The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals

Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function

Dilute carbon in H₃S under pressure

Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

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