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Showing 1–3 of 3 results
Advanced filters: Author: Tiemen J. Wendel Clear advanced filters

  • CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.

    • Sidrit Uruci
    • Daphne E. C. Boer
    • Martijn S. Luijsterburg
    ResearchOpen Access
    Nature
    P: 1-10

  • Affinity-selection platforms are powerful tools in early drug discovery, but current technologies such as DNA-encoded libraries (DELs) are limited by synthesis complexity and incompatibility with nucleic acid binding targets. Here, the authors present a barcode-free self-encoded library (SEL) platform that enables direct screening of over half a million small molecules in a single experiment.

    • Edith van der Nol
    • Nils Alexander Haupt
    • Sebastian Pomplun
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • An inhibitor of NAPE-PLD involved in lipid biosynthesis lowers levels of the endocannabinoid anandamide and other N-acylethanolamines in cells and mouse brain and activates the hypothalamus–pituitary–adrenal axis and impaired fear extinction.

    • Elliot D. Mock
    • Mohammed Mustafa
    • Mario van der Stelt
    Research
    Nature Chemical Biology
    Volume: 16, P: 667-675