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Showing 1–11 of 11 results
Advanced filters: Author: Tim Gilberger Clear advanced filters

  • Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13 protofilaments arranged in a hollow cylinder. Using CryoEM and subvolume averaging, Ferreira and Pražák et al. show that Plasmodium does not adhere to a single microtubule structure. Instead, the cytoskeleton changes substantially to produce a unique, fit for purpose structure and organisation at each stage of its life cycle.

    • Josie L. Ferreira
    • Vojtěch Pražák
    • Kay Grünewald
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment rates of 75% to promote future studies on gametocyte biology.

    • Sylwia D. Boltryk
    • Armin Passecker
    • Till S. Voss
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Rhoptries are essential organelles for invasion of erythrocytes by Plasmodium. Here, the authors characterize the rhoptry-associated protein CERLI1 using quantitative super-resolution microscopy, showing that it is important for parasite invasion and secretion of rhoptry proteins including vaccine antigens.

    • Benjamin Liffner
    • Sonja Frölich
    • Danny W. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.

    • Sudhir Kumar
    • Manish Kumar
    • Pushkar Sharma
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • ThePlasmodium falciparum parasite that causes malaria has a complex life cycle in human erythrocytes. Using time-lapse three-dimensional imaging, the authors show the intraerythrocytic stages of the parasite and provide new insight into the export of P. falciparumproteins to Maurer's clefts.

    • Christof Grüring
    • Arlett Heiber
    • Tobias Spielmann
    Research
    Nature Communications
    Volume: 2, P: 1-11

  • Pazicky et al. describe the structures of glideosome trimeric complexes consisting of myosin A, essential light chain (ELC) and myosin light chain in T. gondii and P. falciparum. They show that ELCs enhance MyoA performance by inducing secondary structure in MyoA, stiffening its lever arm and calcium binding has no influence on ELC structure. These findings provide insight into this important virulence machinery.

    • Samuel Pazicky
    • Karthikeyan Dhamotharan
    • Christian Löw
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14

  • In this Review, De Nizet al. discuss the contribution of key imaging tools to advances in our understanding of Plasmodiumspp. biology and host–pathogen interactions over the past decade. These advances, pertaining to parasite structure and motility, as well as the liver and blood stages, have led to paradigm shifts in our knowledge of malaria.

    • Mariana De Niz
    • Paul-Christian Burda
    • Volker T. Heussler
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 37-54