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Showing 1–10 of 10 results
Advanced filters: Author: Timothy D. Silverstein Clear advanced filters

  • A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

    • Andrew H. Tyner
    • Anna Lou Abatayo
    • Timothy M. Errington
    Research
    Nature
    Volume: 652, P: 143-150

  • A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

    • Olivia Miske
    • Anna Lou Abatayo
    • Timothy M. Errington
    Research
    Nature
    Volume: 652, P: 126-134

  • Expression quantitative trait loci (eQTL) analysis in patients with inflammatory bowel disease identify potential target genes for IBD GWAS loci not readily detected in individuals without disease highlighting the importance disease-focused studies.

    • Nina C. Nishiyama
    • Sophie Silverstein
    • Terrence S. Furey
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • One may participate in the next workshop by submitting monoclonal antibodies (mAbs) that react with molecules on the surface of human leukocytes, platelets or endothelial cells, by carrying out investigations on the mAb panels sent out by the workshop, or by attending the concluding meeting.

    • Timothy A. Springer
    Comments & Opinion
    Nature
    Volume: 354, P: 415-416

  • Cisplatin forms intrastrand cross-links on DNA and is a widely used chemotherapy agent. Among human translesion DNA polymerases, Pol-η can bypass cisplatin adducts. The crystal structure of human Pol-η in complex with a DNA template with a cisplatin lesion is now presented. In addition to the larger active site, the structure reveals specific interactions with the adduct by residues that are not conserved in other translesion polymerases.

    • Ajay Ummat
    • Olga Rechkoblit
    • Aneel K Aggarwal
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 628-632

  • Keng et al. characterize the mouse hepatocellular carcinoma genome by using tissue-specific recombinase expression to restrict mobilization of the Sleeping Beauty transposon to the liver. High throughput sequencing of >100,000 insertions sites in mouse tumor nodules identifies potential therapeutic targets.

    • Vincent W Keng
    • Augusto Villanueva
    • David A Largaespada
    Research
    Nature Biotechnology
    Volume: 27, P: 264-274

  • Ultraviolet radiation causes damage to DNA in skin cells, blocking DNA replication and causing mutations that can lead to cancer. One way in which the cell deals with such damage involves specialized DNA polymerases, such as Polη, that can bypass lesions. Here the crystal structure is presented of Pol? in complex with a thymine–thymine dimer and with undamaged DNA. The bulky thymine dimer is accommodated in an atypically large active site, and stabilized by interactions not found in other polymerases.

    • Timothy D. Silverstein
    • Robert E. Johnson
    • Aneel K. Aggarwal
    Research
    Nature
    Volume: 465, P: 1039-1043

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594