Nature Search

Messenger RNA Stability and Polarity in the lac Operon of Escherichia coli

TIMOTHY CARTER
AUSTIN NEWTON
Research16 Aug 1969
Nature

Volume: 223, P: 707-710
Divergent homeo box proteins recognize similar DNA sequences in Drosophila

Timothy Hoey
Michael Levine
Research28 Apr 1988
Nature

Volume: 332, P: 858-861
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Another folding problem?

Timothy J. Richmond
News & Views01 Mar 1987
Nature

Volume: 326, P: 18-19
Chromatin remodelling drives immune cell–fibroblast communication in heart failure

Conditional deletion of the transcriptional co-activator Brd4 in infiltrating Cx3cr1⁺ mouse macrophages ameliorates heart failure and substantially reduces fibroblast activation.

Michael Alexanian
Arun Padmanabhan
Deepak Srivastava
Research23 Oct 2024
Nature

Volume: 635, P: 434-443
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A transcriptional switch governs fibroblast activation in heart disease

BET proteins regulate a reversible transcriptional switch that governs fibroblast activation in heart disease through the transcription factor MEOX1.

Michael Alexanian
Pawel F. Przytycki
Deepak Srivastava
Research23 Jun 2021
Nature

Volume: 595, P: 438-443
ABHD5 cleaves HDAC4 to benefit the heart

A study in Nature Metabolism reveals a hitherto-unknown enzymatic and physiological role of ABHD5, which acts as a protease that couples extracellular cues to the epigenome of cardiomyocytes by cleaving histone deacetylase 4 (HDAC4).

Joshua G. Travers
Timothy A. McKinsey
News & Views15 Nov 2019
Nature Metabolism

Volume: 1, P: 1034-1035
Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Fiona Allum
Xiaojian Shao
Elin Grundberg
Amendments and Corrections29 Jul 2015
Nature Communications

Volume: 6, P: 1
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

In patients with DNA damage response-deficient solid tumors, the oral ATR kinase inhibitor camonsertib was well tolerated; a recommended phase 2 dose was identified; and encouraging anti-tumor activity was observed, with the highest response rate observed in patients with ovarian cancer.

Timothy A. Yap
Elisa Fontana
Ezra Rosen
ResearchOpen Access05 Jun 2023
Nature Medicine

Volume: 29, P: 1400-1411
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Currently, genome-wide methylation studies are limited to using targeted arrays or enrichment to assess large sample sizes. Here, Allum et al. demonstrate MethylC-Capture Sequencing, a cost-effective method for investigating genetic and epigenetic variation.

Fiona Allum
Xiaojian Shao
Elin Grundberg
ResearchOpen Access29 May 2015
Nature Communications

Volume: 6, P: 1-12
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases.

Nick Craddock
Matthew E. Hurles
Peter Donnelly
Research01 Apr 2010
Nature

Volume: 464, P: 713-720
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Timothy Travers
Cesar A. López
S. Gnanakaran
ResearchOpen Access31 May 2018
Scientific Reports

Volume: 8, P: 1-15
Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Cesar A. López
Timothy Travers
S. Gnanakaran
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-17
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18

Search

Messenger RNA Stability and Polarity in the lac Operon of Escherichia coli

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Another folding problem?

Chromatin remodelling drives immune cell–fibroblast communication in heart failure

A second update on mapping the human genetic architecture of COVID-19

A transcriptional switch governs fibroblast activation in heart disease

ABHD5 cleaves HDAC4 to benefit the heart

Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

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