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Communications Biology (1)

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Lactate orchestrates the TGFβ pathway and ferroptosis nexus in organ fibrosis via USP2 lactylation

TGFβ1 and ferroptosis drive organ fibrosis, with unclear crosstalk. USP2 deubiquitinates TXNDC5 (activating TGFβ signalling) and TFRC (promoting ferroptosis). TGFβ1 lactylates USP2 to boost its activity, highlighting USP2 as a therapeutic target

Jiaqing Xiang
Guangyan Yang
Zhen Liang
ResearchOpen Access28 Nov 2025
Communications Biology

Volume: 8, P: 1-17

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Lactate orchestrates the TGFβ pathway and ferroptosis nexus in organ fibrosis via USP2 lactylation

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