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Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

Multicolour soliton microcombs generation currently lacks spectral tunability and uses degenerate optical parametric oscillators (OPOs). Here, authors demonstrate the class of hyperparametric solitons in a silicon-nitride microresonator nondegenerate OPO, which is pumped in the C-band and producing a tuneable signal in the O-band.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Molecules of solitons provide insight into fundamental interactions between them and the underlying nonlinear system. The reported heteronuclear molecules, comprised of dissipative solitons with distinct frequencies, temporal widths, and energies enter the multistability regime and yield in interlocked frequency combs.

While catalytic reduction of quinolines has gained interest as a way to provide direct and efficient access to tetrahydroquinolines or 1,2-dihydroquinolines, the catalytic synthesis of 1,2-dihydroquinolines remains underdeveloped. Here, the authors demonstrate a catalytic 1,2-reduction of quinolines using a dinuclear aluminum complex.

Stable and tunable integrated lasers are fundamental building blocks for applications from spectroscopy to imaging and communication. Here the authors present a narrow linewidth hybrid photonic integrated laser with low frequency noise and fast linear wavelength tuning. They then provide an efficient FMCW LIDAR demonstration.

’Here the authors provide the demonstration of platicon comb generation in an integrated photonic chip using laser self-injection locking, They take advantage of platicons generation in normal GVD resonators, which significantly relaxes the material and geometry design restrictions

Here, the authors generate dissipative Kerr solitons with stable repetition rates and low optical power threshold. They achieve this by actively switching the bias current of injection-locked III-V semiconductor lasers and pulse-pumping crystalline and integrated microresonators with picosecond laser pulses.

Here, the authors find the missing link for soliton microcombs that exist at the boundary where the group velocity dispersion of light changes sign: zero-dispersion solitons. The resulting microresonator frequency comb, based in Si3N4, spans almost an octave.

By monolithically integrating piezoelectric actuators on ultralow-loss photonic circuits, soliton microcombs—a spectrum of sharp lines over a range of optical frequencies—can be modulated at high speeds with megahertz bandwidths.

A dissipative Kerr soliton crystal state is a temporally ordered regular ensemble of soliton pulses within a cavity. Chaotic driving of optical resonators enables the defect-free creation and dynamical characterization of these states.

Self-injection locking of the pump laser for a soliton microcomb has significantly relaxed the requirements for laser drives. Here the authors study self-injection locking in experiment and theory and reveal that the soliton formation is feasible with detunings unreachable according to previous theories.

The direct generation of mid-infrared optical frequency combs in the region 2.5–4.0 μm from a 1.55-μm conventional and compact erbium-fibre-based femtosecond laser is demonstrated via coherent dispersive wave generation in silicon nitride nanophotonic waveguides.

Song et al. identify two protein-targeting pathways from the endoplasmic reticulum to (1) early lipid droplets (LDs) and (2) mature lipid droplets. They define key factors mediating the second, late pathway and its many cargoes.

A massively parallel coherent light detection and ranging (lidar) scheme using a soliton microcomb—a light source that emits a wide spectrum of sharp lines with equally spaced frequencies—is described.

The genome of the biofuel crop switchgrass (Panicum virgatum) reveals climate–gene–biomass associations that underlie adaptation in nature and will facilitate improvements of the yield of this crop for bioenergy production.

Nanophotonic microwave synthesizers in the X-band (10 GHz, for radar) and K-band (20 GHz, for 5G), based on integrated soliton microcombs driven by a low-noise fibre laser, link the fields of microwave photonics and integrated microcombs.

Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.

A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

Chung et al. identify the protein spartin, linked to Troyer syndrome, as a lipophagy receptor for lipid droplet clearance in vitro and in vivo. The data suggest that impaired lipid droplet turnover may contribute to Troyer syndrome development.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Up to three distinct frequency combs are simultaneously generated from an optical microresonator and a continuous-wave laser, enabling the deployment of dual- and triple-comb-based methods to applications unachievable by current technologies.