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Showing 1–7 of 7 results
Advanced filters: Author: Todd Demarco Clear advanced filters

  • Current HIV animal models, which use macaques or mice, have known limitations. Here, the authors develop a model of HIV-1 infection in owl monkeys, small neotropical primates, expanding experimental opportunities for advancing HIV-1 research.

    • Nicholas R. Meyerson
    • Vanessa L. Bauer
    • Sara L. Sawyer
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • The likelihood of severe COVID-19 increases with age upon SARS-CoV-2 infection and even milder disease manifestations might differ among age groups. Here authors show, by immune transcriptome analysis of samples from the upper respiratory tract and peripheral blood of participants from different age groups, that interferon responses are more typical for the young, while activation of myeloid, inflammatory, and coagulation pathways is exclusive to adults.

    • Jillian H. Hurst
    • Aditya A. Mohan
    • Matthew S. Kelly
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The specifics of the pediatric immune response that gives rise to antibodies capable of neutralising diverse HIV-1 strains is not fully understood. Here the authors characterise the immune environment of Simian-HIV infected paediatric macaques and link to antibody neutralisation induction.

    • Sommer Holmes
    • Hui Li
    • Wilton B. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, and protect animals from other sarbecoviruses.

    • Dapeng Li
    • David R. Martinez
    • Barton F. Haynes
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.

    • Kevin O. Saunders
    • Esther Lee
    • Barton F. Haynes
    Research
    Nature
    Volume: 594, P: 553-559