Nature Search

Melting at the base of a terrestrial magma ocean controlled by oxygen fugacity

The melting behaviour of Earth’s primitive mantle was strongly sensitive to changes in oxygen fugacity, according to high-pressure experiments on pyrolite under different redox conditions.

Yanhao Lin
Takayuki Ishii
Ho-Kwang Mao
ResearchOpen Access16 Jul 2024
Nature Geoscience

Volume: 17, P: 803-808
Enzyme Defect in a Case of Tyrosinemia Type I, Acute Form

Nobuaki Furukawa
Akihiko Kinugasa
Tetsuro Takamatsu
Research01 May 1984
Pediatric Research

Volume: 18, P: 463-466
Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

Volume: 653, P: 444-454
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Complete agreement of the post-spinel transition with the 660-km seismic discontinuity

Takayuki Ishii
Rong Huang
Tomoo Katsura
ResearchOpen Access20 Apr 2018
Scientific Reports

Volume: 8, P: 1-6
Bridgmanite’s ferric iron content determined Earth’s oxidation state

As bridgmanite crystallized from a reduced magma ocean, it left an oxidized lower mantle that may explain the oxidation state of the current upper mantle after mixing, according to high-pressure and high-temperature multi-anvil experiments.

Fei Wang
Lin Wang
Tomoo Katsura
ResearchOpen Access23 Jun 2025
Nature Geoscience

Volume: 18, P: 670-674
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Estimation of “Selective” Intravenous Gamma Globulin Treatment Indicated by Harada Score

Mamoru Ayusawa
Hiroshi Kanamaru
Kensuke Harada
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 181
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
High-pressure synthesis of ultraincompressible hard rhenium nitride pernitride Re₂(N₂)(N)₂ stable at ambient conditions

High pressure experiments may yield materials with unusual combinations of properties, but typically in small amounts and unstable. Here the authors synthesize millimeter-sized samples of metallic, ultraincompressible and very hard rhenium nitride pernitride, recoverable at ambient conditions.

Maxim Bykov
Stella Chariton
Leonid Dubrovinsky
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-8
Buoyancy of slabs and plumes enhanced by curved post-garnet phase boundary

Experimental determination of how the post-garnet phase transition pressure varies with temperature suggests a downward-convex phase boundary with potential implications for mantle dynamics.

Takayuki Ishii
Daniel J. Frost
Tomoo Katsura
Research27 Jul 2023
Nature Geoscience

Volume: 16, P: 828-832
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Depressed 660-km discontinuity caused by akimotoite–bridgmanite transition

X-ray diffraction experiments indicate that the depression of the Earth’s 660-kilometre seismic discontinuity beneath cold subduction zones is caused by a phase transition from akimotoite to bridgmanite, leading to slab stagnation.

Artem Chanyshev
Takayuki Ishii
Tomoo Katsura
ResearchOpen Access05 Jan 2022
Nature

Volume: 601, P: 69-73
Sharp 660-km discontinuity controlled by extremely narrow binary post-spinel transition

The post-spinel transition in mantle composition, which occurs at 660-km depth in Earth’s mantle, takes place over a pressure range equivalent to 250 m in depth, according to multi-anvil experiments for realistic mantle compositions and temperatures.

Takayuki Ishii
Rong Huang
Tomoo Katsura
Research23 Sept 2019
Nature Geoscience

Volume: 12, P: 869-872
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Synthesis of paracrystalline diamond

A study describes the synthesis, structural characterization and formation mechanism of a paracrystalline state of diamond, adding an unusual form of diamond to the family of carbon-based materials.

Hu Tang
Xiaohong Yuan
Huiyang Gou
Research24 Nov 2021
Nature

Volume: 599, P: 605-610
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy

Kensuke Kataoka
Keishi Oda
Yasuhiro Kondoh
ResearchOpen Access22 Aug 2023
Scientific Reports

Volume: 13, P: 1-8
Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma

Akihiro Fujikawa
Asako Nagahira
Masaharu Noda
ResearchOpen Access09 Feb 2016
Scientific Reports

Volume: 6, P: 1-16
Phase relations of bridgmanite, the most abundant mineral in the Earth’s lower mantle

Bridgmanite is the most abundant mineral in the Earth’s lower mantle, with an ideal composition of MgSiO₃, and with many substitution variants with Fe²⁺, Fe³⁺, Al, Ca and H. Here, the author reviews the phase relationships of bridgmanite with coexisting phases as a function of pressure, temperature, and oxygen fugacity.

Tomoo Katsura
ReviewsOpen Access01 Feb 2025
Communications Chemistry

Volume: 8, P: 1-15

Search

Melting at the base of a terrestrial magma ocean controlled by oxygen fugacity

Enzyme Defect in a Case of Tyrosinemia Type I, Acute Form

Host control of persistent Epstein–Barr virus infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Complete agreement of the post-spinel transition with the 660-km seismic discontinuity

Bridgmanite’s ferric iron content determined Earth’s oxidation state

Blood DNA virome associates with autoimmune diseases and COVID-19

Estimation of “Selective” Intravenous Gamma Globulin Treatment Indicated by Harada Score

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

High-pressure synthesis of ultraincompressible hard rhenium nitride pernitride Re₂(N₂)(N)₂ stable at ambient conditions

Buoyancy of slabs and plumes enhanced by curved post-garnet phase boundary

Mapping the human genetic architecture of COVID-19

Depressed 660-km discontinuity caused by akimotoite–bridgmanite transition

Sharp 660-km discontinuity controlled by extremely narrow binary post-spinel transition

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Synthesis of paracrystalline diamond

A second update on mapping the human genetic architecture of COVID-19

A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy

Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma

Phase relations of bridgmanite, the most abundant mineral in the Earth’s lower mantle

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