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Signal Transduction and Targeted Therapy (3)
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Showing 1–8 of 8 results

Advanced filters: Author: Tongmei Zhang Clear advanced filters

Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease

He, Wang, Shen, Dong and colleagues find that unsaturated fatty acids enriched in a black rice diet inhibit amyloid pathology, rescue cognition and restore physiological lifespan in mouse models of Alzheimer’s disease via allosteric activation of GPR120.

Aodi He
Yue Wang
Youming Lu
ResearchOpen Access19 Dec 2025
Nature Aging

Volume: 6, P: 181-199
HER2 expression in cervical squamous cell carcinoma: high prevalence of HER2-low/ultralow and spatiotemporal heterogeneity across tumor evolution

Wei Liu
Xiaojiang Wang
Dan Hu
ResearchOpen Access28 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-10
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial

Dan-Yun Ruan
Wen-Wen Huang
Hongyun Zhao
ResearchOpen Access28 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-12
EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation

Tongmei Zhang
Luting Yang
Gang Wang
ResearchOpen Access03 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-13
A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive-stage small cell lung cancer

Zhiwei Chen
Jianhua Chen
Xiaohui Yu
ResearchOpen Access13 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-8
PINK1-mediated Drp1^S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission

Qingtao Gao
Runyi Tian
Zhuohua Zhang
ResearchOpen Access15 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-16
Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease

Henok Kessete Afewerky
Hao Li
Youming Lu
ResearchOpen Access27 Jan 2022
Scientific Reports

Volume: 12, P: 1-17
Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinoma

Junda Fan
Yu Chen
Cheng Huo
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-16