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Nature Communications (2)
Cell Death Discovery (1)

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Showing 1–3 of 3 results

Advanced filters: Author: Tongran Zhang Clear advanced filters

Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism

Human stem cell–derived β cells accumulate high basal PEP, which disrupts glucose-stimulated insulin release. Restoring PKM1 lowers basal PEP and improves glucose responses, advancing the maturation of stem cell–derived islets for diabetes therapy.

Haopeng Lin
Xin Liu
Huisheng Liu
ResearchOpen Access21 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Directed differentiation of pancreatic δ cells from human pluripotent stem cells

Human pancreatic δ cells play important roles in the balance of pancreatic hormones. Here, the authors develop a directed differentiation method to generate in vitro and in vivo functional δ cells from human stem cells by combining FGF2 with FGF7.

Lihua Chen
Nannan Wang
Huisheng Liu
ResearchOpen Access27 Jul 2024
Nature Communications

Volume: 15, P: 1-22
Biomolecular condensates in lung cancer: from molecular mechanisms to therapeutic targeting

Nannan Wang
Qianqian Liu
Huisheng Liu
ReviewsOpen Access06 Oct 2025
Cell Death Discovery

Volume: 11, P: 1-9