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Nature Biomedical Engineering (1)

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Discovery of high-affinity ligands for prostatic acid phosphatase via DNA-encoded library screening enables targeted cancer therapy

Screening of DNA-encoded chemical libraries against prostatic acid phosphatase yielded OncoACP3, a modular small organic ligand with picomolar binding affinity that enabled targeted payload delivery to prostate cancer.

Tony Georgiev
Francesca Migliorini
Samuele Cazzamalli
Research26 Jun 2025
Nature Biomedical Engineering

Volume: 10, P: 178-191

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Discovery of high-affinity ligands for prostatic acid phosphatase via DNA-encoded library screening enables targeted cancer therapy

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