Nature Search

The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

Yoriyoshi Kimura
Hisashi Koga
Mitsuyoshi Nakao
Research01 Aug 1998
Nature Medicine

Volume: 4, P: 915-922
Bio-essential sugars in samples from asteroid Bennu

Samples returned from asteroid Bennu contain bio-essential sugars such as ribose and glucose that may have formed in the parent asteroid from brines containing formaldehyde, according to a geochemical study.

Yoshihiro Furukawa
Sako Sunami
Dante S. Lauretta
ResearchOpen Access02 Dec 2025
Nature Geoscience

Volume: 19, P: 19-24
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY-CRC01

The phase 2 trial, DESTINYCRC01, previously demonstrated durable activity of trastuzumab deruxtecan (T-DXd) in patients with HER2-positive metastatic colorectal cancer refractory to standard treatment. Here, the authors report the exploratory analysis of the DESTINY-CRC01 trial investigating markers of response or resistance to T-DXd.

Salvatore Siena
Kanwal Raghav
Takayuki Yoshino
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-12
Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu

Rocks and dust from the asteroid Bennu contain some of the molecular building blocks of life on Earth, such as amino acids and nucleobases. They also carry ammonia that formed billions of years ago in cold, distant regions of our Solar System.

Daniel P. Glavin
Jason P. Dworkin
Dante S. Lauretta
ResearchOpen Access29 Jan 2025
Nature Astronomy

Volume: 9, P: 199-210
Publisher Correction: HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY-CRC01

Salvatore Siena
Kanwal Raghav
Takayuki Yoshino
Amendments and CorrectionsOpen Access15 Jan 2025
Nature Communications

Volume: 16, P: 1
Breunnerite grain and magnesium isotope chemistry reveal cation partitioning during aqueous alteration of asteroid Ryugu

Returned samples from the carbonaceous asteroid Ryugu provide pristine information on the original aqueous alteration history of the Solar System. Here, the authors utilize Breunnerite grain and magnesium isotope chemistry to reveal cation partitioning during aqueous alteration of asteroid Ryugu.

Toshihiro Yoshimura
Daisuke Araoka
Yoshinori Takano
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

In this study, the authors report primordial aqueous alteration signatures in water-soluble organic molecules from the carbonaceous asteroid Ryugu. This provides evidence o coevolutionary aqueous alteration between water and organics in this asteroid.

Yoshinori Takano
Hiroshi Naraoka
Shogo Tachibana
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu

The asteroid Ryugu samples are by far the freshest extraterrestrial carbonaceous material. The authors report soluble ions and organic sulfur molecules linked with primordial brine and prebiotic organic evolution of the primitive asteroid.

Toshihiro Yoshimura
Yoshinori Takano
Yuki Kimura
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-11
Uracil in the carbonaceous asteroid (162173) Ryugu

Uracil was identified in the sample returned from the asteroid Ryugu. Having been provided to the early Earth as a component in such asteroidal materials, these molecules might have played a role for prebiotic chemical evolution on the early Earth

Yasuhiro Oba
Toshiki Koga
Yuichi Tsuda
ResearchOpen Access21 Mar 2023
Nature Communications

Volume: 14, P: 1-9
A new family of extraterrestrial amino acids in the Murchison meteorite

Toshiki Koga
Hiroshi Naraoka
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-8
Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites

All DNA/RNA nucleobases were identified in carbonaceous meteorites. Having been provided to the early Earth as a component in carbonaceous meteorites, these molecules might have played a role for the emergence of genetic functions in early life.

Yasuhiro Oba
Yoshinori Takano
Hiroshi Naraoka
ResearchOpen Access26 Apr 2022
Nature Communications

Volume: 13, P: 1-10
Soluble organic matter Molecular atlas of Ryugu reveals cold hydrothermalism on C-type asteroid parent body

The molecular atlas of soluble organic compounds from Ryugu shows unprecedented molecular complexity and diversity resulting from alteration on a low temperature, water rich parent body.

Philippe Schmitt-Kopplin
Norbert Hertkorn
Yasuhiro Oba
ResearchOpen Access16 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Optimal blood pressure target for patients with prior stroke: A systematic review and meta-analysis

Toshiki Maeda
Yuichiro Ohya
Masatoshi Koga
Research17 Mar 2025
Hypertension Research

Volume: 48, P: 1859-1869
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Yuki Hitomi
Kazuko Ueno
Minoru Nakamura
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup

A subgroup analysis of the EXCITE-HT study according to age (<65 and ≥65 years) showed that esaxerenone achieved the pre-defined non-inferiority margin to trichlormethiazide in its BP-lowering effect regardless of age. In patients aged ≥65 years, esaxerenone achieved the superiority margin to trichlormethiazide in lowering SBP.

Kazuomi Kario
Hiroyuki Ohbayashi
Mitsuru Ohishi
ResearchOpen Access28 Mar 2025
Hypertension Research

Volume: 48, P: 1586-1598
Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker

A subgroup analysis of the EXCITE-HT study according to basal antihypertensive agent demonstrated the non-inferiority of esaxerenone to trichlormethiazide in lowering morning home BP regardless irrespective of the basal antihypertensive agent. Esaxerenone with a CCB showed superiority to trichlormethiazide in lowering SBP, without any new safety concerns.

Kazuomi Kario
Hiroyuki Ohbayashi
Mitsuru Ohishi
ResearchOpen Access12 Oct 2024
Hypertension Research

Volume: 48, P: 506-518
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12

Search

The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

Bio-essential sugars in samples from asteroid Bennu

Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY-CRC01

Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu

Publisher Correction: HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY-CRC01

Breunnerite grain and magnesium isotope chemistry reveal cation partitioning during aqueous alteration of asteroid Ryugu

Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu

Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu

Uracil in the carbonaceous asteroid (162173) Ryugu

A new family of extraterrestrial amino acids in the Murchison meteorite

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites

Soluble organic matter Molecular atlas of Ryugu reveals cold hydrothermalism on C-type asteroid parent body

Optimal blood pressure target for patients with prior stroke: A systematic review and meta-analysis

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup

Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker

Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

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