Nature Search

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

Shuichi Igarashi
Reiji Koide
Shoji Tsuji
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 111-117
Visualizing and identifying single atoms using electron energy-loss spectroscopy with low accelerating voltage

Electron energy-loss spectroscopy (EELS) is broadly used to examine chemical composition, but single-atom analysis is hampered by the damage caused by incident electrons. Now, with an EELS technique that does not cause such damage, single calcium atoms have been identified and various elemental analyses demonstrated using metallofullerene-doped nanotubes.

Kazu Suenaga
Yuta Sato
Yukihito Kondo
Research05 Jul 2009
Nature Chemistry

Volume: 1, P: 415-418
The Effects of a Selective cAMP Phosphodiesterase Inhibitor, Rolipram, on Methamphetamine-Induced Behavior

Masaomi Iyo
Yohko Maeda
Susumu Fukui
Research01 Aug 1995
Neuropsychopharmacology

Volume: 13, P: 33-39
Burkholone, A New Cytotoxic Antibiotic against IGF-I Dependent Cells from Burkholderia sp.

Toshiya Mori
Tomoki Yamashita
Kazuo Shin-ya
Research01 Nov 2007
The Journal of Antibiotics

Volume: 60, P: 713-716
Na⁺-V-ATPase inhibitor curbs VRE growth and unveils Na⁺ pathway structure

The authors identify V-161, a compound that inhibits enterococcal Na⁺-V-ATPase and reduces VRE colonization in mice. The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic insights.

Kano Suzuki
Yoshiyuki Goto
Takeshi Murata
Research21 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 450-458
Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study

Chika Kubota
Toshiya Inada
Norio Ozaki
ResearchOpen Access05 Dec 2018
Scientific Reports

Volume: 8, P: 1-7
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’

Tomoya Isobe
Masatoshi Takagi
Junko Takita
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

The receptor TLR3 is essential for effective responses to herpes simplex virus type 1. Miyake and colleagues demonstrate that a neuron- and astrocyte-intrinsic pathway of TLR3 and the metabolic checkpoint kinase complex mTORC2 is needed to prevent fulminant infection with this virus and encephalitis.

Ryota Sato
Akihisa Kato
Kensuke Miyake
Research10 Sept 2018
Nature Immunology

Volume: 19, P: 1071-1082
High-power all-solid-state batteries using sulfide superionic conductors

The development of all-solid-state batteries requires fast lithium conductors. Here, the authors report a lithium compound, Li_9.54Si_1.74P_1.44S_11.7Cl_0.3, with an exceptionally high conductivity and demonstrate that all-solid-state batteries based on the compound have high power densities.

Yuki Kato
Satoshi Hori
Ryoji Kanno
Research21 Mar 2016
Nature Energy

Volume: 1, P: 1-7
Expanded polyglutamine stretches interact with TAF_II130, interfering with CREB-dependent transcription

Takayoshi Shimohata
Toshihiro Nakajima
Shoji Tsuji
Research01 Sept 2000
Nature Genetics

Volume: 26, P: 29-36
MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Altered transcriptional machinery promotes aberrant self-renewal of non-stem hematopoietic progenitors. Here the authors show that AF10 fusion proteins cause aberrant self-renewal via ENL, which promotes leukemic transformation by binding to MOZ/MORF lysine acetyltransferases

Yosuke Komata
Akinori Kanai
Akihiko Yokoyama
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Detection of the CTG repeat expansion in congenital myotonic dystrophy

Kazuhiro Ohya
Nobutada Tachi
Shunzo Chiba
Research01 Mar 1997
Japanese Journal of Human Genetics

Volume: 42, P: 169-180
Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional activity of the complex.

Dominique Ray-Gallet
M. Daniel Ricketts
Geneviève Almouzni
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Forward-genetics analysis of sleep in randomly mutagenized mice

Two mutations affecting the sleep–wakefulness balance in mice are detected, showing that the SIK3 protein kinase is essential for determining daily wake time, and the NALCN cation channel regulates the duration of rapid eye movement sleep.

Hiromasa Funato
Chika Miyoshi
Masashi Yanagisawa
Research02 Nov 2016
Nature

Volume: 539, P: 378-383
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

The glycosaminoglycan chondroitin sulphate inhibits axon growth. Here the authors show that mice deficient in chondroitin sulphate biosynthesis have increased levels of heparan sulphate, which is more efficient than chondroitinase in supporting recovery from spinal cord injury.

Kosei Takeuchi
Nozomu Yoshioka
Michihiro Igarashi
ResearchOpen Access12 Nov 2013
Nature Communications

Volume: 4, P: 1-11
A complex hydride lithium superionic conductor for high-energy-density all-solid-state lithium metal batteries

All-solid-state batteries could deliver high energy densities without using organic liquid electrolytes. Here the authors report a complex hydride Li-ion conductor 0.7Li(CB₉H₁₀)–0.3Li(CB₁₁H₁₂) that exhibits impressive ionic conductivity and other electrochemical characteristics in an all-solid-state cell.

Sangryun Kim
Hiroyuki Oguchi
Shin-ichi Orimo
ResearchOpen Access06 Mar 2019
Nature Communications

Volume: 10, P: 1-9
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Repeated inversions within a pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The harlequin ladybird beetle, Harmonia axyridis, has remarkable phenotypic diversity, with over 200 colour patterns. Here, Ando et al. show that this patterning is regulated by the transcription factor gene pannier and has diversified by repeated inversions and cis-regulatory modifications of pannier.

Toshiya Ando
Takeshi Matsuda
Teruyuki Niimi
ResearchOpen Access21 Sept 2018
Nature Communications

Volume: 9, P: 1-13
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

Kenji Sakimura
Tatsuya Kutsuwada
Masayoshi Mishina
Research12 Jan 1995
Nature

Volume: 373, P: 151-155
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Masaki Igarashi
Yoshiko Nakagawa-Nagahama
Toshimasa Yamauchi
ResearchOpen Access01 May 2022
npj Aging

Volume: 8, P: 1-11
Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation

Satoshi Iwata
Yuya Sato
Shuki Mizutani
Research19 Jan 1999
Oncogene

Volume: 18, P: 165-172
Combined treatment with mesenchymal stem cells and therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a phase 1/2 randomized trial

Kazuko Wada
Akihito Takeuchi
Satoshi Kusuda
ResearchOpen Access10 May 2025
Scientific Reports

Volume: 15, P: 1-8
Metabolic dysfunction-associated steatotic liver disease and gallbladder polyp development: an observational study

Masahiro Sogabe
Toshiya Okahisa
Tetsuji Takayama
ResearchOpen Access28 Sept 2024
Scientific Reports

Volume: 14, P: 1-8
Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Yuichiro Fukamizu
Yoshiaki Uchida
Takanobu Sakurai
ResearchOpen Access24 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
A cross-sectional study assessing the relationship between non-alcoholic fatty liver disease and periodontal disease

Satsuki Sato
Yohei Kamata
Masato Minabe
ResearchOpen Access10 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer

Tomonori Habuchi
Takeshi Takahashi
Tetsuro Kato
Research12 Mar 2001
Oncogene

Volume: 20, P: 531-537
Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study

Keima Tose
Tsunehiko Takamura
Atsushi Sekiguchi
ResearchOpen Access22 Jan 2024
Molecular Psychiatry

Volume: 29, P: 891-901
Role of the membrane potential in mitochondrial protein unfolding and import

Takehiro K. Sato
Shin Kawano
Toshiya Endo
ResearchOpen Access21 May 2019
Scientific Reports

Volume: 9, P: 1-11
Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice

Yoshifumi Kida
Toshiya Okahisa
Tetsuji Takayama
ResearchOpen Access18 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
Comparison of the role of alcohol consumption and qualitative abdominal fat on NAFLD and MAFLD in males and females

Masahiro Sogabe
Toshiya Okahisa
Tetsuji Takayama
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43

Toshiya Sato
Kanako Oda
Minesuke Yokoyama
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1

Hiroko Ida-Yonemochi
Wataru Morita
Kosei Takeuchi
ResearchOpen Access20 Nov 2018
Scientific Reports

Volume: 8, P: 1-15
CdsA is involved in biosynthesis of glycolipid MPIase essential for membrane protein integration in vivo

Katsuhiro Sawasato
Ryo Sato
Ken-ichi Nishiyama
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Divergent mechanisms of reduced growth performance in Betula ermanii saplings from high-altitude and low-latitude range edges

Takaki Aihara
Kyoko Araki
Yoshihiko Tsumura
ResearchOpen Access09 Nov 2023
Heredity

Volume: 131, P: 387-397
Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder

Shintaro Ogawa
Kotaro Hattori
Hiroshi Kunugi
ResearchOpen Access15 Jan 2015
Scientific Reports

Volume: 5, P: 1-8
Arpp, a New Homolog of Carp, Is Preferentially Expressed in Type 1 Skeletal Muscle Fibers and Is Markedly Induced by Denervation

Yoshiyuki Tsukamoto
Takao Senda
Masatsugu Moriyama
Research01 May 2002
Laboratory Investigation

Volume: 82, P: 645-655
Formation of novel transition metal hydride complexes with ninefold hydrogen coordination

Shigeyuki Takagi
Yuki Iijima
Shin-ichi Orimo
ResearchOpen Access13 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
Advent of Continents: A New Hypothesis

Yoshihiko Tamura
Takeshi Sato
Alexander Nichols
ResearchOpen Access27 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance

Toshiya Matsukawa
Hideko Motojima
Hiroko Isoda
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells

Satoru Shinriki
Mayumi Hirayama
Hirotaka Matsui
ResearchOpen Access14 Oct 2022
Leukemia

Volume: 36, P: 2605-2620
Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area

Fumiko Goto
Yuji Kiyama
Toshiya Manabe
Research08 Jan 2022
Molecular Psychiatry

Volume: 27, P: 1694-1703
Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma

K Miyahara
K Nouso
Hiroki Takayama
ResearchOpen Access17 Sept 2013
British Journal of Cancer

Volume: 109, P: 2072-2078
The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse

In this report, the authors sought to determine whether expression of cadherin 11 in mesenchymal cells plays a critical role in ear morphogenesis. Cadherin 11 knockout mice show moderate hearing loss. The air-filled area of auditory bulla is reduced and residual mesenchymal cells are observed in the middle ear. This mutant mouse may be a promising animal model for elucidating the causes of conductive hearing loss.

Yuji Kiyama
Yayoi S. Kikkawa
Toshiya Manabe
Research02 Jul 2018
Laboratory Investigation

Volume: 98, P: 1364-1374

Search

Filter By:

Search

Quick links