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Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Vaccines against the WA1 SARS-CoV2 strain confer protection against other variants. However, the mechanisms underlying cross-protection are not fully understood. Here, the authors develop a method for rapid analysis of single B cells from patient samples and show that infection with a variant elicits convergent, public B cell responses to other variants.

Noemia S. Lima
Maryam Musayev
Daniel C. Douek
ResearchOpen Access14 Dec 2022
Nature Communications

Volume: 13, P: 1-14
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

mRNA-1273, an mRNA vaccine that encodes a stabilized prefusion-state severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, elicits robust immune responses and protects mice against replication of SARS-CoV-2 in the upper and lower airways.

Kizzmekia S. Corbett
Darin K. Edwards
Barney S. Graham
Research05 Aug 2020
Nature

Volume: 586, P: 567-571
CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns

Respiratory syncytial virus is a major pathogen with burden observed and associated with childhood infection. Here the authors characterise a cationic adjuvant formulation and show single immunisation results in protection in a murine neonate model of respiratory syncytial virus infection.

Simon D. van Haren
Gabriel K. Pedersen
Ofer Levy
ResearchOpen Access02 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Structural insights from vaccine candidates for EV-D68

The cryo-EM structures of EV-D68 virus-like particles, inactivated virus particles, and altered virus particles from B3 and A2 subclades were determined, offering structural insights that relate to vaccine development.

Jiaxuan Cheng
Peter W. Krug
Peter D. Kwong
ResearchOpen Access04 Jun 2025
Communications Biology

Volume: 8, P: 1-12
An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

Brooke Bollman
Naveen Nunna
Andrea Carfi
ResearchOpen Access20 Apr 2023
npj Vaccines

Volume: 8, P: 1-10
Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera

Hadi M. Yassine
Patrick M. McTamney
Barney S. Graham
ResearchOpen Access05 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
The road to approved vaccines for respiratory syncytial virus

Tracy J. Ruckwardt
ReviewsOpen Access25 Sept 2023
npj Vaccines

Volume: 8, P: 1-8

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Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns

Structural insights from vaccine candidates for EV-D68

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera

The road to approved vaccines for respiratory syncytial virus

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