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Showing 1–6 of 6 results
Advanced filters: Author: Trisha R. Berger Clear advanced filters

  • Components of the glycocalyx have been shown to impair immune cell functions, including of CAR-T cells. Here the authors show that CAR-T cell mediated cytotoxicity in pancreatic cancer models can be enhanced by incorporating non-signalling binding domains that target the glycocalyx.

    • Sangwoo Park
    • Cassidy E. Ho
    • Marcela V. Maus
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Promising clinical activity of Claudin (CLDN) 18.2-directed CAR-T cell therapy in patients with gastric cancer has been recently reported, however gastrointestinal toxicities have also been described. Here the authors recapitulate the on-target off-tumor toxicity of CLDN18.2-directed CAR-T cells due to gastric mucosa damage in preclinical models, suggesting an AND-gate strategy targeting CLDN18.2 and mesothelin to overcome CAR-T cell toxicity

    • Filippo Birocchi
    • Antonio J. Almazan
    • Marcela V. Maus
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Patients with myeloma multiple treated with BCMA CAR T cells often relapse with BCMA-negative disease or antigen escape. Here the authors describe the design of TACI-directed single and dual CAR T cells with in vitro and in vivo activity against multiple myeloma, overcoming BCMA antigen loss.

    • Rebecca C. Larson
    • Michael C. Kann
    • Marcela V. Maus
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • A genome-wide CRISPR knockout screen in a model of glioblastoma shows that killing by chimeric antigen receptor T cells requires interferon-γ receptor-dependent adhesion to tumour cells, but cytotoxicity of liquid tumours does not rely on this pathway.

    • Rebecca C. Larson
    • Michael C. Kann
    • Marcela V. Maus
    Research
    Nature
    Volume: 604, P: 563-570

  • We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.

    • Daniel J. Benjamin
    • James O. Berger
    • Valen E. Johnson
    Comments & Opinion
    Nature Human Behaviour
    Volume: 2, P: 6-10