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Showing 1–7 of 7 results

Advanced filters: Author: Trond Ulven Clear advanced filters

Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors

Multiple ligands can bind to G protein-coupled receptors at the same time. Here, authors develop a resonance energy transfer approach to study simultaneous binding of two fluorescent ligands to the same receptor.

Alice Valentini
Bethany Dibnah
Elisabeth Rexen Ulven
ResearchOpen Access11 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Allosteric modulation and biased signalling at free fatty acid receptor 2

Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.

Xuan Zhang
Abdul-Akim Guseinov
Cheng Zhang
Research18 Jun 2025
Nature

Volume: 643, P: 1428-1438
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

The first small-molecule inhibitor of chemoattractant GPCR OXE-R disrupts signaling downstream of Gβγ but not Gα_i/o, providing evidence that signaling bias can occur between Gβγ and Gα subunits within a heterotrimer.

Stefanie Blättermann
Lucas Peters
Evi Kostenis
Research27 May 2012
Nature Chemical Biology

Volume: 8, P: 631-638
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

Estela Lorza-Gil
Gabriele Kaiser
Susanne Ullrich
ResearchOpen Access05 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms

Daiane F. Engel
Vanessa C. D. Bobbo
Licio A. Velloso
ResearchOpen Access06 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Eugenia Sergeev
Anders Højgaard Hansen
Graeme Milligan
ResearchOpen Access23 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Zobaer Al Mahmud
Laura Jenkins
Graeme Milligan
ResearchOpen Access20 Dec 2017
Scientific Reports

Volume: 7, P: 1-15