Akira Tanave, Yuji Imai, and Tsuyoshi Koide find that nested retrotransposition is the cause of the classical nonagouti mutation. They identify a β4 element that was integrated into an intronic VL30 retrovirus in the agouti gene, leading to abnormal splicing and nonagouti coat color, and show that this allele likely arose in an East Asian mouse lineage.
- Akira Tanave
- Yuji Imai
- Tsuyoshi Koide