Nguyen, Ozgur et al. applied resonance Raman Spectroscopy (RRS) to monitor mitochondrial redox states in rat and pig livers during reperfusion after warm ischemia, including resolving redox changes at complexes III and IV. RRS detects early mitochondrial hyperoxidation, particularly at complex III and that RRS guided treatment with methylene blue can restore function in injured livers, highlighting its potential for improving organ assessment and rescue in transplantation.
- Khanh T. Nguyen
- O. Sila Ozgur
- Shannon N. Tessier
