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Molecular Psychiatry (13)
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Showing 1–50 of 61 results

Advanced filters: Author: Udo Müller Clear advanced filters

Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety

Marius Gruber
Jan Schulte
Jonathan Repple
ResearchOpen Access12 Jan 2026
Neuropsychopharmacology

P: 1-10
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Analysis of plant metabolites – the baseline-threshold principle

Katja Neubauer
Jenny Bandomir
Kerstin Schmidt
MultimediaOpen Access14 May 2010
Nature Precedings

P: 1
Analysis of plant metabolites – the baseline-threshold principle

Katja Neubauer
Jenny Bandomir
Kerstin Schmidt
MultimediaOpen Access11 May 2010
Nature Precedings

P: 1
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Author Correction: Fine-mapping genomic loci refines bipolar disorder risk genes

Maria Koromina
Ashvin Ravi
Niamh Mullins
Amendments and CorrectionsOpen Access27 Oct 2025
Nature Neuroscience

Volume: 28, P: 2644-2645
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

Male offspring of pregnant mice infected with a low dose of Zika virus infection have increased testosterone levels, an increased number of immature neurons in apical hippocampal dendrites and are less likely to survive in utero infection than female littermates.

Stephanie Stanelle-Bertram
Kerstin Walendy-Gnirß
Gülsah Gabriel
Research10 Sept 2018
Nature Microbiology

Volume: 3, P: 1161-1174
Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Δ⁹-THC): No Influence on Neuropsychological Performance

Kirsten R Müller-Vahl
Heidrun Prevedel
Udo Schneider
Research14 Feb 2003
Neuropsychopharmacology

Volume: 28, P: 384-388
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 282-291
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Multi-source connectivity as the driver of solar wind variability in the heliosphere

Solar wind is highly structured yet variable. Close-up observations of the solar atmosphere reveal that the changing connectivity of multiple sources in the solar corona drives the observed complexity and variability in the inner heliosphere.

Stephanie L. Yardley
David H. Brooks
Udo Schühle
ResearchOpen Access28 May 2024
Nature Astronomy

Volume: 8, P: 953-963
Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling

Alexandra Winter
Marius Gruber
Udo Dannlowski
ResearchOpen Access15 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4613-4621
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

5-hydroxymethyluracil (hmU) is an oxidative DNA lesion and a potential intermediate in DNA repair–coupled DNA demethylation pathways. Isotopic labeling and MS reveal that hmU is produced directly by Tet-mediated oxidation of thymine in mouse embryonic stem cells, suggesting a functional role for hmU in stem cells.

Toni Pfaffeneder
Fabio Spada
Thomas Carell
Research18 May 2014
Nature Chemical Biology

Volume: 10, P: 574-581
Sequence-specific DNA binding determined by contacts outside the helix-turn-helix motif of the ParB homolog KorB

Dheeraj Khare
Günter Ziegelin
Udo Heinemann
Research30 May 2004
Nature Structural & Molecular Biology

Volume: 11, P: 656-663
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Kira Flinkenflügel
Marius Gruber
Udo Dannlowski
ResearchOpen Access01 May 2024
Molecular Psychiatry

Volume: 29, P: 3151-3159
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype

Yevgeniya Atiskova
Susanne Bartsch
Udo Bartsch
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-15
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Wang, Philpott et al. perform integrative genomic, transcriptomic and proteomic analyses across fibroid, myometrium, and endometrium tissues to uncover mechanisms underlying uterine fibroid (UF) associated heavy menstrual bleeding. Signalling from MED12-mutated fibroids alters RNA splicing events in the endometrium.

Chen-Yi Wang
Martin Philpott
Adam P. Cribbs
ResearchOpen Access31 Jul 2025
Communications Medicine

Volume: 5, P: 1-16
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins

Thomas Schwartz
Joachim Behlke
Alexander Rich
Research01 Sept 2001
Nature Structural Biology

Volume: 8, P: 761-765
49 INSULIN-LIKE GROWTH FACTOR(IGF)AND CARRIER PROTEIN SERUM LEVELS IN TALL GIRLS ON HIGH-DOSE ESTROGENS

Udo Heinrich
Klaus Hartmann
Dieter Schönberg
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 611
Brain structural correlates of an impending initial major depressive episode

Anna Kraus
Katharina Dohm
Udo Dannlowski
ResearchOpen Access12 Mar 2025
Neuropsychopharmacology

Volume: 50, P: 1176-1185
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
A ternary AppA–PpsR–DNA complex mediates light regulation of photosynthesis-related gene expression

The repressor–antirepressor complex AppA–PpsR is a transcriptional regulator that permits Rhodobacter to switch between photosynthesis and respiration in response to light and oxygen. A combination of crystallography, hydrogen/deuterium-exchange MS and binding assays shows how illumination reduces the affinity of the complex for DNA and provides insight into the mechanism of signal transduction by photoreceptors.

Andreas Winkler
Udo Heintz
Ilme Schlichting
Research02 Jun 2013
Nature Structural & Molecular Biology

Volume: 20, P: 859-867
Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder

Jonathan Repple
Marco Mauritz
Martijn P. van den Heuvel
Research22 Nov 2019
Molecular Psychiatry

Volume: 25, P: 1550-1558
Brain structural correlates of recurrence following the first episode in patients with major depressive disorder

Hannah Lemke
Hannah Klute
Udo Dannlowski
ResearchOpen Access27 Aug 2022
Translational Psychiatry

Volume: 12, P: 1-9
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Childhood maltreatment and cognitive functioning: the role of depression, parental education, and polygenic predisposition

Janik Goltermann
Ronny Redlich
Udo Dannlowski
ResearchOpen Access14 Aug 2020
Neuropsychopharmacology

Volume: 46, P: 891-899
Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study

Susanne Meinert
Nico Nowack
Udo Dannlowski
ResearchOpen Access25 Oct 2021
Molecular Psychiatry

Volume: 27, P: 1103-1110
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Xueyi Shen
Yara J. Toenders
Greig de Zubicaray
ResearchOpen Access19 Aug 2025
Molecular Psychiatry

Volume: 31, P: 611-621
Reduced fractional anisotropy in depressed patients due to childhood maltreatment rather than diagnosis

Susanne Meinert
Jonathan Repple
Udo Dannlowski
Research05 Aug 2019
Neuropsychopharmacology

Volume: 44, P: 2065-2072
Systematic misestimation of machine learning performance in neuroimaging studies of depression

Claas Flint
Micah Cearns
Tim Hahn
ResearchOpen Access06 May 2021
Neuropsychopharmacology

Volume: 46, P: 1510-1517
Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization

Louisa Müller-Miny
Katharina Thiel
Jan D. Lünemann
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder

Tim Hahn
Nils R. Winter
Jonathan Repple
ResearchOpen Access13 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1057-1063
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Hugh Markus, Peter Donnelly and colleagues report a genome-wide association study for ischemic stroke. They identify a SNP in HDAC9, a histone deacetylase gene, that is associated with large vessel ischemic stroke and suggest subtype-specific associations to ischemic stroke.

Céline Bellenguez
Steve Bevan
Hugh S Markus
Research05 Feb 2012
Nature Genetics

Volume: 44, P: 328-333
Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls

Florian Thomas-Odenthal
Kai Ringwald
Tilo Kircher
ResearchOpen Access29 Mar 2024
Molecular Psychiatry

Volume: 29, P: 2724-2732
Biological sex classification with structural MRI data shows increased misclassification in transgender women

Claas Flint
Katharina Förster
Dominik Grotegerd
ResearchOpen Access09 Apr 2020
Neuropsychopharmacology

Volume: 45, P: 1758-1765
Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning

Helena Pelin
Marcus Ising
Till F. M. Andlauer
ResearchOpen Access14 Jun 2021
Neuropsychopharmacology

Volume: 46, P: 1895-1905
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia

Angeliki Spathopoulou
Gabriella A. Sauerwein
Frank Edenhofer
ResearchOpen Access29 Apr 2024
Molecular Psychiatry

Volume: 29, P: 3128-3140
Genetic factors influencing a neurobiological substrate for psychiatric disorders

Till F. M. Andlauer
Thomas W. Mühleisen
Sven Cichon
ResearchOpen Access29 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-13
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

Nils Opel
Anbupalam Thalamuthu
Udo Dannlowski
ResearchOpen Access28 May 2020
Molecular Psychiatry

Volume: 26, P: 4839-4852
Characterisation of S. aureus/MRSA CC1153 and review of mobile genetic elements carrying the fusidic acid resistance gene fusC

Stefan Monecke
Elke Müller
Ralf Ehricht
ResearchOpen Access14 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair

Marcos Seoane
Sophia Buhs
Martin A. Horstmann
ResearchOpen Access16 Jan 2019
Oncogene

Volume: 38, P: 3616-3635

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