Nature Search

Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells

Nuclear architecture depends on proper regulation of lamin A/C modifications. Here, the authors show that TAF4A and NF-Y control Kansl2 expression in muscle stem cells, preserving genome stability and supporting muscle regeneration.

Angelina M. Georgieva
Krishna Sreenivasan
Thomas Braun
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Structural analyses define the molecular basis of clusterin chaperone function

The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.

Patricia Yuste-Checa
Alonso I. Carvajal
Andreas Bracher
ResearchOpen Access08 Aug 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2035-2045
Reporter proteins for in vivo fluorescence without oxygen

Thomas Drepper
Thorsten Eggert
Karl-Erich Jaeger
Research11 Mar 2007
Nature Biotechnology

Volume: 25, P: 443-445
Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine

Smooth muscle cell-specific knockout of Tet3 in mice leads to loss of intragenic 5-hydroxymethylcytosine, accumulation of spurious transcripts and TLR7/8-mediated lung inflammation resembling asthma in human lung samples.

Fan Wu
Xiang Li
Thomas Braun
ResearchOpen Access20 Dec 2022
Nature Genetics

Volume: 55, P: 100-111
Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

Utrophin is a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin. Here the authors report that inactivation of the protein deacetylase SIRT6, involved in the deacetylation of the epigenetic mark H3K56ac in muscle cells, increases expression of utrophin and ameliorates dystrophic muscle pathology in mice.

Angelina M. Georgieva
Xinyue Guo
Thomas Braun
ResearchOpen Access20 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Visualizing chaperonin function in situ by cryo-electron tomography

Visualizing chaperonin complexes in their natural cellular environment using cryo-electron tomography, the authors propose a GroEL–GroES reaction cycle that consists of linked asymmetrical and symmetrical subreactions mediating protein folding.

Jonathan Wagner
Alonso I. Carvajal
F. Ulrich Hartl
ResearchOpen Access21 Aug 2024
Nature

Volume: 633, P: 459-464
Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

The Hsp70 system prevents protein aggregation and increases folding yields, but it is unknown whether it also enhances the rate of folding. Here the authors combine refolding assays, FRET and hydrogen/deuterium exchange-mass spectrometry measurements to study the folding of firefly luciferase and find that the bacterial Hsp70 actively promotes the folding of this multi-domain protein.

Rahmi Imamoglu
David Balchin
F. Ulrich Hartl
ResearchOpen Access17 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Jan Dreute
Julia Stengel
M. Lienhard Schmitz
ResearchOpen Access23 Jun 2025
Cell Death & Differentiation

Volume: 32, P: 2239-2256
Novel 3D in situ visualization of seal heartworm (Acanthocheilonema spirocauda) larvae in the seal louse (Echinophthirius horridus) by X-ray microCT

David Ebmer
Stephan Handschuh
Carlos Hermosilla
ResearchOpen Access18 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3

Anna Gärtner
Anna Joëlle Ruff
Ulrich Schwaneberg
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Praveen K. Dhandapani
Isabel M. Begines-Moreno
Marten Szibor
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice

Alexander Perniss
Nadine Schmidt
Wolfgang Kummer
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome

Julia Richter
Andreas Hüttmann
Wolfram Klapper
CorrespondenceOpen Access19 Aug 2019
Blood Cancer Journal

Volume: 9, P: 1-4
Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight

Antoine Elias
Tobias Weber
Nandu Goswami
ResearchOpen Access05 Feb 2024
npj Microgravity

Volume: 10, P: 1-17
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Thrombosis as an intravascular effector of innate immunity

Thrombosis is the most frequent cause of mortality worldwide. In this Review, the authors propose that thrombosis might also have a conserved physiological role in immune defence via a process termed immunothrombosis. However, if uncontrolled, immunothrombosis facilitates pathological clot formation.

Bernd Engelmann
Steffen Massberg
Reviews07 Dec 2012
Nature Reviews Immunology

Volume: 13, P: 34-45

Search

Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells

Structural analyses define the molecular basis of clusterin chaperone function

Reporter proteins for in vivo fluorescence without oxygen

Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine

Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

Visualizing chaperonin function in situ by cryo-electron tomography

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Novel 3D in situ visualization of seal heartworm (Acanthocheilonema spirocauda) larvae in the seal louse (Echinophthirius horridus) by X-ray microCT

A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice

Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome

Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Thrombosis as an intravascular effector of innate immunity

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